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Details for anatomical structure: Purkinje cell

EndoNet ID: ENC00265

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Synonyms

Purkinje cell, , Neuron piriforme (purkinjiense)

General information

Found in the Purkinje cell layer of cerebellar cortex

Links to other resources

Cytomer cy0011416

Larger structures

  • brain
  • circulatory_system__hematopoietic_system
  • cerebellum
  • nerve
  • central_nerve_system_element
  • cerebellar_cortex

Substructures

    Secreted hormones

    • Hormone: NRG-1

    • Hormone: noggin

    • Hormone: GABA

      Influenced by:

      • CB1
        in hippocampus

    • Hormone: Granulin-1

    • Hormone: FAM3B-b

    Receptors

    • Receptor: alpha 1A-adrenoreceptor

      Induced phenotype:

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 1A ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells. [1]

    • Receptor: alpha 1B-adrenoreceptor

      Induced phenotype:

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 1B ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells. [1]

    • Receptor: alpha 1D-adrenoreceptor

    • Receptor: alpha-2A adrenoreceptor

      Induced phenotype:

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [2]

    • Receptor: alpha-2B adrenoreceptor

      Induced phenotype:

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [2]

    • Receptor: alpha-2C adrenoreceptor

      Induced phenotype:

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [2]

    • Receptor: 5-ht-5 receptor

    • Receptor: GABAA receptor

    • Receptor: GluR-2

    • Receptor: GluR-4

    • Receptor: GluR-1

    • Receptor: EAAT4

      Induced phenotype:

      • glutamate transport
        • EAAT4 controls the transport of glutamate by different anion fluxes. [3]
    Reference