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Details for anatomical structure: pneumocyte type II

EndoNet ID: ENC00459

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Synonyms

pneumocyte type II, great alveolar cell, Epitheliocytus magnus (granularis)

General information

secreting surfactant, which prevent the alveoli from collapsing by reducing the surface tension

Links to other resources

Cytomer cy0011190

Larger structures

  • parts_of_human_body
  • lung

Substructures

    Secreted hormones

    • Hormone: lipocalin 2

      • Synthesis of NGAL increases dramatically in bronchial epithelial cells and alveolear type II pneumocytes during lung inflammation. [1]

      Influenced by:

      • IL-1RI
        in pneumocyte_type_II
        • IL-1beta induces a >10-fold up-regulation of NGAL expression in the type II pneumocyte-derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect. [1]

    • Hormone: IL-8

      Influenced by:

      • IL-1RI
        in pneumocyte_type_II
      • TNFR1
        in pneumocyte_type_II

    Receptors

    • Receptor: TNFR1

      Influences:

      • IL-8

    • Receptor: TLR4

    • Receptor: IL-1RI

      Influences:

      • lipocalin 2
        • IL-1beta induces a >10-fold up-regulation of NGAL expression in the type II pneumocyte-derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect. [1]
      • IL-8
    Reference