Details for anatomical structure: oligodendrocyte
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- General information
- Related structures
- Hormones
- Receptors
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
oligodendrocyte, , OligodendrocytusGeneral information
Oligodendrocyte are present in both gray matter and white matter; forms the myelin sheaths in central nervous system.Links to other resources
Cytomer | cy0011359 |
Related structures
Larger structures
- area_postrema_of_pons
- isocortex
- glial_cell_of_central_nervous_system
- brain
- peripheral_nerve_system_element
- epiphysis
- pituitary_gland_of_diencephalon
- arcuate_nucleus_of_hypothalamus
- spinal_cord
- hippocampus
- tegmentum_of_mesencephalon
- internal_ear
- cerebral_cortex
- amygdaloid_body
- suprachiasmatic_nucleus_of_hypothalamus
- posterior_raphe_nucleus_of_midbrain
- cerebellar_cortex
- brain_stem
- periventricular_nucleus_of_hypothalamus
- thalamus
- cerebellum
- corpus_striatum
- corpus_callosum
- pallidum
- substantia_nigra
- central_nerve_system_element
- medulla_oblongata
- supra-optic_nucleus
- lateral_hypothalamic_area
- reticular_part_of_substantia_nigra
- pyramidal_layer_of_hippocampus
- circulatory_system__hematopoietic_system
- red_nucleus
- parts_of_human_body
- hypothalamus
- white_matter
- nerve
Substructures
Secreted hormones
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Hormone: APOD
Receptors
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Receptor: Sphingosine 1-phosphate receptor 5
Induced phenotype:
- regulation of myelination
- S1P5 expressed by oligodendrocytes might play a role in normal myelination and in demyelinating diseases, such as multiple sclerosis, as its expression is restricted to oligodendrocytes throughout development from immature stages to myelin-forming cells. [1]
- regulation of myelination
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Receptor: integrin alpha-6/beta-1
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Receptor: GLAST
Induced phenotype:
- excitotoxcicity
- The uptake of glutamate from the synaptic cleft by GLAST is crucial for the termination of excitatory neurotransmission. thereby preventing pathologic excitotoxicity. [2]
- excitotoxcicity
-
Receptor: Lysophosphatidic acid receptor 1
Induced phenotype:
-
Receptor: Lysophosphatidic acid receptor 3
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Receptor: Psychosine receptor
Induced phenotype:
- positive regulation of glial cell apoptosis
- Psy is primarily accumulated in oligodendroglia, which contain abundant GalCer, a precursor of Psy. The accumulated Psy is cytotoxic, and these cells were therefore injured or died on Psy accumulation, probably due to apoptosis. [6]
- positive regulation of glial cell apoptosis