Status
Please wait ...

Details for messenger / hormone: DHT

EndoNet ID: ENH00003

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • DHT
  • 5alphaDHT
  • dehydrotestosterone
  • 17beta-hydroxy-5alpha-androstan-3-one
  • 5-alpha-dihydrotestosterone
  • Boldenone
  • 1,4-Androstadien-17b-ol-3-one
  • 3-Oxo-17b-hydroxy-1,4-androstadien

General information

  • Androgen, a derivative of testosterone formed by the conversion of testosterone in the action of 5alpha-reductase isozymes. [1]
  • Testrosterone is converted to DHT in tissues expressing 5alpha-reductase. [2]
  • Tissues which exress 5alpha-reductase and exhibit androgenic effects that are dependent on DHT: hair follicles, liver, kidney, adrenals, seminal vesicles, prostate, testes,foreskin, and scrotum. [2]
  • The involvement of both androgen receptor and ERbeta in mediating DHEA-, DHT-, and E(2)-induced the prostate specific antigen expression in prostate cancer cells. [3]
  • The prostate highly expresses 5alpha-reductase and the effects of testosterone in promoting prostate enlargement and cancer are both mediated by DHT. [2]

Classification

Hormone function

  • reproduction and sexual differentiation
    • sexual differentiation

    Chemical classification

    • hormone
      • not genome-encoded
        • sterol lipids
          • steroids
            • androgens

      Composition

      KEGG C03917

      Links to other resources

      KEGG C03917
      LIPID MAPS LMST02020018
      LipidBank SST0148

      • Anatomical structure: Leydig_cell_of_testis

      • Anatomical structure: theca_cell

      • Anatomical structure: adrenal_cortex

        • DHT significantly reduces human adrenocortical cell growth in vitro. DHT-induced growth inhibition could be mediated at least in part by TGFb1. [4]

      Targets

      CellARSHBG-R
      adrenal cortex Present
      Influences
      • ↑ TGF-beta 1
      cell of apocrine sweat gland Present
      eccrine sweat glands Present
      Phenotypes
      • positive regulation of perspiration
      epidermis Present
      Phenotypes
      • negative regulation of epidermal barrier function
      • acne vulgaris
      granulosa cell Present
      Phenotypes
      • ovarian follicle development
      growth plate Present
      Phenotypes
      • regulation of pubertal skeletal growth
      • positive regulation of bone mineralization
      hair follicle Present
      Phenotypes
      • hair growth
      • alopecia
      • hirsutism
      heart Present
      Phenotypes
      • cardiac hypertrophy
      liver Present
      Phenotypes
      • mediation of effects from thymus on liver
      osteoblast Present
      Influences
      • ↑ IGF-1
      • ↓ IGFBP-4
      • ↑ IGFBP-2
      • ↑ IGFBP-3
      prostate Present
      Phenotypes
      • Androgen insensitivity syndromes
      		Present
      Influences
      • ↑ free PSA
      sebaceous glands Present
      Phenotypes
      • sebaceous gland development
      skeleton muscle Present
      theca cell Present
      Phenotypes
      • ovarian follicle development
      • polycystic ovary syndrome
      Reference