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Details for messenger / hormone: estriol

EndoNet ID: ENH00070

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Synonyms

  • estriol
  • trihydroxestrin
  • 1,3,5(10)-Estratriene-3,16-alpha,17beta-triol
  • 16a-hydroxyestradiol
  • estra-1,3,5(10)-triene-3,16,17-triol

General information

  • estriol treatment sensitizes Kupffer cells to lipopolysaccharide via mechanisms dependent on increases in endotoxin receptor in vivo. [1]
  • Steroid. [2]
  • Estriol as a hormone provides a basis for the novel therapeutic use of estriol for multiple sclerosis and other putative T helper 1-mediated autoimmune diseases. [3]
  • Estriol is a potential therapeutic agent to prevent or delay Alzheimer's disease progression. [4]
  • The metabolic effects of estriol summarize to be highly toxic in rat liver. [5]
  • Estriol treatment plays an important role for men in addition to women with multiple sclerosis. [6]
  • Has relatively weak estrogenic activity. [2]
  • About 3 times less potent than estrone. [7]

Classification

Hormone function

  • homeostasis
    • hormone precursor

    Chemical classification

    • hormone
      • not genome-encoded
        • sterol lipids
          • steroids
            • estrogens

      Composition

      KEGG C05141

      Links to other resources

      KEGG C05141
      LIPID MAPS LMST02010003
      LipidBank SST0014

      • Anatomical structure: placenta

      Targets

      Cell
      No records found.
      Reference