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Details for messenger / hormone: antidiuretic hormone

EndoNet ID: ENH00119

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Synonyms

  • Neurophysin-II
  • AVP-NPII
  • vasopressin-neurophysin 2-copeptin
  • antidiuretic hormone
  • ADH
  • argipressin
  • vasopressin
  • VP
  • arginine vasopressin
  • AVP

General information

  • The syndrome of inappropriate secretion of antidiuretic hormone can develop secondary to severe S. stercoralis infection. [1]
  • ADH plays an important role during chronic stresses. [2]
  • Human and all other mammals except pig. [3]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
      • further hormone secretion

      Chemical classification

      • hormone
        • genome-encoded
          • vasopressin/oxytocin family

        Composition

        Arg-vasopressin

        Sequence 
        CYFQNCPRG

        Neurophysin 2

        Sequence 
        AMSDLELRQ CLPCGPGGK GRCFGPSIC 
CADELGCFV GTAEALRCQ EENYLPSPC 
QSGQKACGS GGRCAAFGV CCNDESCVT 
EPECREGFH RRA

        Vasopressin-neurophysin 2-copeptin

        Sequence 
        MPDTMLPAC FLGLLAFSS ACYFQNCPR 
GGKRAMSDL ELRQCLPCG PGGKGRCFG 
PSICCADEL GCFVGTAEA LRCQEENYL 
PSPCQSGQK ACGSGGRCA AFGVCCNDE 
SCVTEPECR EGFHRRARA SDRSNATQL 
DGPAGALLL RLVQLAGAP EPFEPAQPD 
AY
        UniProt P01185
        KEGG 551

        Copeptin

        • Copeptin (...) was found to be a stable and sensitive marker for AVP release, analogous to C-peptide for Insulin. Copeptin measurement has been shown to be useful in various clinical indications, including the diagnosis of diabetes insipidus and the monitoring of sepsis and cardiovascular diseases. [4]
        Sequence 
        ASDRSNATQ LDGPAGALL LRLVQLAGA 
PEPFEPAQP DAY

        Links to other resources

        UniProt P01185
        Ensembl ENST00000380293
        KEGG 551

        • Anatomical structure: paraventricular_nucleus_of_hypothalamus

          • Expression of vasopressin (VP) mRNA in the human paraventricular nuclei. [5]
          • Is stored in the neurohypophysis. [6]

        • Anatomical structure: supra-optic_nucleus

          • Is stored in the neurohypophysis. [6]
          • Expression of vasopressin (VP) mRNA in the human supraoptic nuclei. [5]

          Influenced by:

          • thyroid hormone receptor beta 2
            in paraventricular_nucleus_of_hypothalamus
            • TRH is colocalized with vasopressin in the supraoptic and paraventricular nuclei and can participate in the regulation og biosynthesis and secretion of vasopressin [7]
            • TRH stimulates vasopressin biosynthesis in young rats [7]

        • Anatomical structure: neurohypophysis

          Influenced by:

          • CRF-R1
            in brain
            • Basal HPA axis may be affected by magnocellular CRF that directly stimulates the AVP secretion through a paracrine mechanism at the level of neurohemal zone of the neurohypophysis. [8]

        • Anatomical structure: hypothalamus

          Influenced by:

          • CXCR4
            in hypothalamus
            • In acute stimulation conditions, such as an increase in osmolarity or Angiotensin II, SDF-1/CXCL12 co-localized with AVP can be somatodendritically released and inhibit AVP release by an autoregulatory mechanism involving its receptor CXCR4. In conditions in which AVP is chronically stimulated, such as dehydration, SDF-1/CXCL12 is strongly released, resulting in a down-regulation of CXCR4. Such down-regulation of the receptor blocks the inhibitory effect of SDF-1/CXCL12 on AVP release, allowing a sustained increase in AVP secretion. [9]

        • Anatomical structure: thymus

          • The neuropeptide vasopressin is synthesized in the human thymus in a similar manner as in the hypothalamic-neurohypophyseal system. [10]

        Targets

        CellV1bV2
        basophil corticotroph cell of anterior pituitary Present
        Influences
        • ↑ ACTH
        kidney Present
        		Present
        Phenotypes
        • X-linked nephrogenic diabetes insipidus
        lung Present
        thymus Present
        Phenotypes
        • regulation of T cell differentiation
        Reference