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Details for messenger / hormone: IGFBP-4

EndoNet ID: ENH00193

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Synonyms

  • IGFBP-4
  • insulin-like growth factor binding protein 4
  • IBP-4
  • IGF-binding protein 4

General information

  • A single 2.6-kb mRNA of IGFBP-4 has been identified with high expression in liver. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • IGFBP family

      Composition

      IGFBP-4

      • The IGFBP-4 gene, located on chromosome 17, contains four exons. [1]
      Sequence 
      DEAIHCPPC SEEKLARCR PPVGCEELV 
REPGCGCCA TCALGLGMP CGVYTPRCG 
SGLRCYPPR GVEKPLHTL MHGQGVCME 
LAEIEAIQE SLQPSDKDE GDHPNNSFS 
PCSAHDRRC LQKHFAKIR DRSTSGGKM 
KVNGAPRED ARPVPQGSC QSELHRALE 
RLAASQSRT HEDLYIIPI PNCDRNGNF 
HPKQCHPAL DGQRGKCWC VDRKTGVKL 
PGGLEPKGE LDCHQLADS FRE
      UniProt P22692

      Links to other resources

      UniProt P22692
      Ensembl ENSG00000141753
      KEGG hsa:3487

      • Anatomical structure: lipocyte_of_liver

        • IGFBP-4 protein levels decreased in response to IGF-I. [2]

      • Anatomical structure: hepatocyte

      • Anatomical structure: osteoblast

        Influenced by:

        • AR
          in osteoblast
          • 5-alpha-DHT decreased IGFBP-4 mRNA and protein levels by 2- and 4-fold. [3]
        • ER-alpha
          in osteoblast
          • Treatment with E2 at 0.01-10 nM for 48 h increased IGFBP-4 mRNA to 346% +/- 90% (mean +/- SE) of control (p < 0.05) and IGFBP-4 protein to 278% +/- 75% of control (p < 0.01) in a dose-dependent fashion. [4]
        • ER-beta
          in osteoblast
          • Treatment with E2 at 0.01-10 nM for 48 h increased IGFBP-4 mRNA to 346% +/- 90% (mean +/- SE) of control (p < 0.05) and IGFBP-4 protein to 278% +/- 75% of control (p < 0.01) in a dose-dependent fashion [4]

      Targets

      Cell
      No records found.
      Reference