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Details for messenger / hormone: IGFBP-6

EndoNet ID: ENH00195

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Synonyms

  • IGFBP-6
  • insulin-like growth factor binding protein 6
  • IBP-6
  • IGF-binding protein 6

General information

  • IGFBP-6 may also have a role in regulating ovarian activity, perhaps by functioning as an antigonadotropin. [1]
  • IGFBP-6 binds both IGF-1 and IGF-2, it has a significantly greater affinity for IGF-2. [2]
  • IGFBP-6 is found in relatively high levels in cerebrospinal fluid. [3]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    • hormone
      • genome-encoded
        • IGFBP family

      Composition

      IGFBP-6

      • The human IGFBP-6 gene is located on chromosome 12 and contains 4 exons. [3]
      Sequence 
      RCPGCGQGV QAGCPGGCV EEEDGGSPA 
EGCAEAEGC LRREGQECG VYTPNCAPG 
LQCHPPKDD EAPLRALLL GRGRCLPAR 
APAVAEENP KESKPQAGT ARPQDVNRR 
DQQRNPGTS TTPSQPNSA GVQDTEMGP 
CRRHLDSVL QQLQTEVYR GAQTLYVPN 
CDHRGFYRK RQCRSSQGQ RRGPCWCVD 
RMGKSLPGS PDGNGSSSC PTGSSG
      UniProt P24592

      Links to other resources

      UniProt P24592
      Ensembl ENSG00000167779
      KEGG hsa:3489

      • Anatomical structure: lipocyte_of_liver

      Targets

      Cell
      No records found.
      Reference