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Details for messenger / hormone: haptoglobin

EndoNet ID: ENH00207

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Synonyms

  • haptoglobin
  • HPT
  • HP

General information

  • Haptoglobin protects against the potentiation of bacterial growth by hemoglobin. [1]
  • Tetramer of 2 alpha chains and 2 beta chains [2]
  • Haptoglobin phenotype is an independent risk factor for cardiovascular disease in individuals with diabetes. [3]
  • Haptoglobin is an unusual secretory protein in that it is proteolytically processed in the endoplasmic reticulum and not in the Golgi. [4]
  • A major function of haptoglobin is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. [5]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded

    Composition

    Haptoglobin beta chain (2 times)

    Sequence 
    ILGGHLDAK GSFPWQAKM VSHHNLTTG 
ATLINEQWL LTTAKNLFL NHSENATAK 
DIAPTLTLY VGKKQLVEI EKVVLHPNY 
SQVDIGLIK LKQKVSVNE RVMPICLPS 
KDYAEVGRV GYVSGWGRN ANFKFTDHL 
KYVMLPVAD QDQCIRHYE GSTVPEKKT 
PKSPVGVQP ILNEHTFCA GMSKYQEDT 
CYGDAGSAF AVHDLEEDT WYATGILSF 
DKSCAVAEY GVYVKVTSI QDWVQKTIA 
EN
    UniProt P00738

    Haptoglobin alpha chain (2 times)

    Sequence 
    VDSGNDVTD IADDGCPKP PEIAHGYVE 
HSVRYQCKN YYKLRTEGD GVYTLNDKK 
QWINKAVGD KLPECEADD GCPKPPEIA 
HGYVEHSVR YQCKNYYKL RTEGDGVYT 
LNNEKQWIN KAVGDKLPE CEAVCGKPK 
NPANPVQ
    UniProt P00738

    Links to other resources

    UniProt P00738
    Ensembl ENST00000355906
    KEGG hsa:3240

    • Anatomical structure: adipose_tissue

      Influenced by:

      • PPARgamma1
        in adipose_tissue

    Targets

    Cell
    No records found.
    Reference