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Details for messenger / hormone: NGF

EndoNet ID: ENH00225

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Synonyms

  • beta-nerve growth factor
  • beta nerve growth factor
  • beta-NGF
  • neurotrophin
  • NGF
  • nerve growth factor
  • nerve growth factor, beta subunit
  • NGFB
  • neurotrophic factor

General information

  • TNFalpha has a strong stimulatory effect on NGF gene expression and NGF release from 3T3-L1 adipocytes, suggesting that the neurotrophin is an inflammatory response protein in adipose tissue. [1]
  • Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems. [2]
  • The target-derived neurotrophin, NGF, is synthesised by the main adipose tissue depots in both rodents and man, and is secreted from white adipocytes. [1]
  • Bradykinin and NGF are 2 such pro-algesic agents that activate G-protein-coupled (BK2) and tyrosine kinase (TrkA) receptors, respectively, to stimulate phospholipase C (PLC) signalling pathways in primary afferent neurons. [3]
  • The unprocessed precursor of NGF, proNGF, is a death-inducing ligand for the neurotrophin receptor p75. [4]
  • Neurotrophins are growth factors that promote cell survival, differentiation, and cell death. [5]
  • Nerve growth factor-beta (NGF) is known as a growth factor for human basophils and has recently been shown to also up-regulate mast cell characteristics in human leukaemic mast cells. [6]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines

      Composition

      unprocessed

      Sequence 
      MSMLFYTLI TAFLIGIQA EPHSESNVP 
AGHTIPQVH WTKLQHSLD TALRRARSA 
PAAAIAARV AGQTRNITV DPRLFKKRR 
LRSPRVLFS TQPPREAAD TQDLDFEVG 
GAAPFNRTH RSKRSSSHP IFHRGEFSV 
CDSVSVWVG DKTTATDIK GKEVMVLGE 
VNINNSVFK QYFFETKCR DPNPVDSGC 
RGIDSKHWN SYCTTTHTF VKALTMDGK 
QAAWRFIRI DTACVCVLS RKAVRRA
      UniProt P01138

      NGF beta, mature peptide.

      Sequence 
      EPHSESNVP AGHTIPQAH WTKLQHSLD 
TALRRARSA PAAAIAARV AGQTRNITV 
DPRLFKKRR LRSPRVLFS TQPPREAAD 
TQDLDFEVG GAAPFNRTH RSKRSSSHP 
IFHRGEFSV CDSVSVWVG DKTTATDIK 
GKEVMVLGE VNINNSVFK QYFFETKCR 
DPNPVDSGC RGIDSKHWN SYCTTTHTF 
VKALTMDGK QAAWRFIRI DTACVCVLS 
RKAVRRA

      Links to other resources

      UniProt P01138
      Ensembl ENST00000369512
      KEGG hsa:4803

      • Anatomical structure: adipose_tissue

        • The target-derived neurotrophin, NGF, is synthesised by the main adipose tissue depots in both rodents and man, and is secreted from white adipocytes. [1]

      • Anatomical structure: fat_cell

        • The target-derived neurotrophin, NGF, is synthesised by the main adipose tissue depots in both rodents and man, and is secreted from white adipocytes. [1]

      Targets

      CellNGF receptorTransient receptor potential cation channel subfamily V member 1trkA
      dorsal root ganglion Present
      Phenotypes
      • sensory perception of pain
      		Present
      Phenotypes
      • thermoception
      mast cell Present
      Phenotypes
      • Pruritus
      spinal cord Present
      Phenotypes
      • sensory perception of pain
      urinary bladder Present
      Phenotypes
      • detection of mechanical stimulus
      • bladder activity
      Reference