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Details for messenger / hormone: CGRP1

EndoNet ID: ENH00228

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  • calcitonin gene-related peptide I
  • calcitonin gene-related peptide 1
  • CGRP1
  • CGRP-I
  • alpha-type CGRP

General information

  • Alternative processing of the RNA transcribed from the calcitonin gene results in the production of an mRNA in neural tissue distinct from that in thyroidal 'C' cells. [1]
  • CGRP, a 37-amino acid neuropeptide, is found in the central nervous system as well as in the heart. [2]
  • Adrenomedullin and CGRP interact with a common receptor of the CGRP1 subtype in the human adrenal zona glomerulosa. [3]


Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded
        • calcitonin family


      isoform 1

      UniProt P06881-1

      Links to other resources

      UniProt P06881
      Ensembl ENST00000486207
      • Anatomical structure: nerve

        Influenced by:

        • CB1
          in adrenal_gland
          • Stimulation of the CB1 receptor results in the inhibition of a range of excitatory and inhibitory neurotransmitters, like acetylcholine, noradrenaline, dopamine, 5-hydroxytryptamine, D-aspartate and cholecystokinin. [4]
      • Anatomical structure: hypothalamus

      • Anatomical structure: corpus_striatum

      • Anatomical structure: amygdaloid_body

      • Anatomical structure: cerebellum