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Details for messenger / hormone: HIF1

EndoNet ID: ENH00230

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Synonyms

  • class E basic helix-loop-helix protein 78
  • PAS domain-containing protein 8
  • Basic-helix-loop-helix-PAS protein MOP1
  • ARNT-interacting protein
  • hypoxia-inducible factor 1-alpha
  • HIF1
  • HIF-1
  • hypoxia-inducible factor 1
  • HIF 1
  • hypoxia inducible factor 1
  • HIF1A
  • hypoxia-inducible factor 1 alpha subunit
  • HIF1-alpha
  • ARNT interacting protein
  • member of PAS protein 1
  • MOP1

General information

  • HIF-1 alpha is stable in hypoxia, but in the presence of oxygen it is targeted for proteasomal degradation by the ubiquitination complex pVHL, the protein of the von Hippel Lindau (VHL) tumour suppressor gene and a component of an E3 ubiquitin ligase complex. [1]
  • HIF-1alpha was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-alpha. [2]
  • Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. [3]
  • HIF-1alpha transactivates genes required for energy metabolism and tissue perfusion and is necessary for embryonic development and tumor explant growth. [4]
  • Stimulation of angiogenesis in adipose tissue through the HIF-1 pathway. [5]
  • HIF-1alpha is essential for myeloid cell-mediated inflammation. [6]
  • Heterodimeric protein consisting of an constitutive beta subunit and an hypoxia-induced alpha subunit. [5]
  • HIF-1 expression is increased in tumours, by ischaemic heart disease, and in the WAT of obese mice. [5]
  • The target genes for HIF-1 include VEGF, PAI-1 and leptin. [5]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • immune response
      • activation

      Chemical classification

      Composition

      UniProt Q16665
      KEGG hsa:3091

      Links to other resources

      UniProt Q16665
      Ensembl ENST00000337138
      KEGG hsa:3091

      • Anatomical structure: fat_cell

        • Expression occurs in both the adipocytes and in the stromal vascular cells, and in the WAT of obese mice the level of the mRNA is markedly increased compared with lean siblings. [5]

      • Anatomical structure: adipose_tissue

        • Expression occurs in both the adipocytes and in the stromal vascular cells, and in the WAT of obese mice the level of the mRNA is markedly increased compared with lean siblings. [5]

      Targets

      Cell
      No records found.
      Reference