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Details for messenger / hormone: complement C3

EndoNet ID: ENH00233

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Synonyms

  • complement C3
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
  • acylation-stimulating protein
  • complement derived factor acylation stimulating protein
  • C3b
  • ASP
  • complement component 3
  • C3
  • PZP-like alpha-2-macroglobulin domain-containing protein 1

General information

  • Genetic knockout of acylation-stimulating protein leads to reduced body fat, obesity resistance and improved insulin sensitivity in mice. [1]
  • ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes. [2]
  • Acylation stimulating protein (ASP) has been shown to be released by white adipocytes. [3]
  • ASP1 is an adipocyte-derived protein that has potent anabolic effects on human adipose tissue for both glucose uptake and non-esterified fatty acid (NEFA) storage. [4]
  • Acylation-stimulating protein (ASP) acts as a paracrine signal to increase triglyceride synthesis in adipocytes. [4]

Classification

Hormone function

Chemical classification

  • hormone
    • genome-encoded
      • Alpha-2-macroglobulin family

    Composition

    Complement C3 alpha chain

    Sequence
    SVQLTEKRM DKVGKYPKE LRKCCEDGM 
    RENPMRFSC QRRTRFISL GEACKKVFL 
    DCCNYITEL RRQHARASH LGLARSNLD 
    EDIIAEENI VSRSEFPES WLWNVEDLK 
    EPPKNGIST KLMNIFLKD SITTWEILA 
    VSMSDKKGI CVADPFEVT VMQDFFIDL 
    RLPYSVVRN EQVEIRAVL YNYRQNQEL 
    KVRVELLHN PAFCSLATT KRRHQQTVT 
    IPPKSSLSV PYVIVPLKT GLQEVEVKA 
    AVYHHFISD GVRKSLKVV PEGIRMNKT 
    VAVRTLDPE RLGREGVQK EDIPPADLS 
    DQVPDTESE TRILLQGTP VAQMTEDAV 
    DAERLKHLI VTPSGCGEQ NMIGMTPTV 
    IAVHYLDET EQWEKFGLE KRQGALELI 
    KKGYTQQLA FRQPSSAFA AFVKRAPST 
    WLTAYVVKV FSLAVNLIA IDSQVLCGA 
    VKWLILEKQ KPDGVFQED APVIHQEMI 
    GGLRNNNEK DMALTAFVL ISLQEAKDI 
    CEEQVNSLP GSITKAGDF LEANYMNLQ 
    RSYTVAIAG YALAQMGRL KGPLLNKFL 
    TTAKDKNRW EDPGKQLYN VEATSYALL 
    ALLQLKDFD FVPPVVRWL NEQRYYGGG 
    YGSTQATFM VFQALAQYQ KDAPDHQEL 
    NLDVSLQLP SRSSKITHR IHWESASLL 
    RSEETKENE GFTVTAEGK GQGTLSVVT 
    MYHAKAKDQ LTCNKFDLK VTIKPAPET 
    EKRPQDAKN TMILEICTR YRGDQDATM 
    SILDISMMT GFAPDTDDL KQLANGVDR 
    YISKYELDK AFSDRNTLI IYLDKVSHS 
    EDDCLAFKV HQYFNVELI QPGAVKVYA 
    YYNLEESCT RFYHPEKED GKLNKLCRD 
    ELCRCAEEN CFIQKSDDK VTLEERLDK 
    ACEPGVDYV YKTRLVKVQ LSNDFDEYI 
    MAIEQTIKS GSDEVQVGQ QRTFISPIK 
    CREALKLEE KKHYLMWGL SSDFWGEKP 
    NLSYIIGKD TWVEHWPEE DECQDEENQ 
    KQCQDLGAF TESMVVFGC PN
    UniProt P01024

    complement C3 beta chain

    Sequence
    SPMYSIITP NILRLESEE TMVLEAHDA 
    QGDVPVTVT VHDFPGKKL VLSSEKTVL 
    TPATNHMGN VTFTIPANR EFKSEKGRN 
    KFVTVQATF GTQVVEKVV LVSLQSGYL 
    FIQTDKTIY TPGSTVLYR IFTVNHKLL 
    PVGRTVMVN IENPEGIPV KQDSLSSQN 
    QLGVLPLSW DIPELVNMG QWKIRAYYE 
    NSPQQVFST EFEVKEYVL PSFEVIVEP 
    TEKFYYIYN EKGLEVTIT ARFLYGKKV 
    EGTAFVIFG IQDGEQRIS LPESLKRIP 
    IEDGSGEVV LSRKVLLDG VQNPRAEDL 
    VGKSLYVSA TVILHSGSD MVQAERSGI 
    PIVTSPYQI HFTKTPKYF KPGMPFDLM 
    VFVTNPDGS PAYRVPVAV QGEDTVQSL 
    TQGDGVAKL SINTHPSQK PLSITVRTK 
    KQELSEAEQ ATRTMQALP YSTVGNSNN 
    YLHLSVLRT ELRPGETLN VNFLLRMDR 
    AHEAKIRYY TYLIMNKGR LLKAGRQVR 
    EPGQDLVVL PLSITTDFI PSFRLVAYY 
    TLIGASGQR EVVADSVWV DVKDSCVGS 
    LVVKSGQSE DRQPVPGQQ MTLKIEGDH 
    GARVVLVAV DKGVFVLNK KNKLTQSKI 
    WDVVEKADI GCTPGSGKD YAGVFSDAG 
    LTFTSSSGQ QTAQRAELQ CPQPAA
    UniProt P01024

    Links to other resources

    UniProt P01024
    Ensembl ENST00000245907
    KEGG hsa:718
    • Anatomical structure: fat_cell

      • Chylomicrons in vitro stimulate ASP production by adipocytes. [4]
    • Anatomical structure: adipose_tissue

      • Chylomicrons in vitro stimulate ASP production by adipocytes. [4]

    Targets

    Cell
    No records found.
    Reference