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Details for messenger / hormone: tissue factor

EndoNet ID: ENH00242

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Synonyms

  • Thromboplastin
  • tissue factor
  • TF
  • coagulation factor III
  • F3
  • tissue thromboplastin
  • CD142 antigen

General information

  • Tissue factor (TF), the primary cellular initiator of the coagulation protease cascade, is implicated in having important roles in hemostasis, thrombogenesis, inflammation, and the cellular immune response. [1]
  • Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation. [2]
  • Tissue factor gene expression in the adipose tissues of obese mice. [3]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • immune response
      • activation

      Chemical classification

      Composition

      unprocessed precursor

      Sequence 
      METPAWPRV PRPETAVAR TLLLGWVFA 
QVAGASGTT NTVAAYNLT WKSTNFKTI 
LEWEPKPVN QVYTVQIST KSGDWKSKC 
FYTTDTECD LTDEIVKDV KQTYLARVF 
SYPAGNVES TGSAGEPLY ENSPEFTPY 
LETNLGQPT IQSFEQVGT KVNVTVEDE 
RTLVRRNNT FLSLRDVFG KDLIYTLYY 
WKSSSSGKK TAKTNTNEF LIDVDKGEN 
YCFSVQAVI PSRTVNRKS TDSPVECMG 
QEKGEFREI FYIIGAVVF VVIILVIIL 
AISLHKCRK AGVGQSWKE NSPLNVS

      Links to other resources

      UniProt P13726
      Ensembl ENST00000334047
      KEGG hsa:2152

      • Anatomical structure: fat_cell

        • Products secreted by adipocytes also include tissue factor. [4]

      • Anatomical structure: adipose_tissue

        • Tissue factor gene expression in the adipose tissues of obese mice. [3]

      • Anatomical structure: pancreatic_islets

        • In vivo markers of thrombosis and of hepatocellular necrosis directly correlated with TF and CCL2/MCP-1 released in vitro by islets. [5]

      Targets

      Cell
      No records found.
      Reference