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Details for messenger / hormone: NRG-1

EndoNet ID: ENH00243

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Synonyms

  • NRG-1
  • glial growth factor
  • sensory and motor neuron-derived factor
  • acetylcholine receptor-inducing activity
  • breast cancer cell differentiation factor p45
  • Heregulin
  • neu differentiation factor
  • pro-neuregulin-1, membrane-bound isoform
  • neuregulin-1
  • neuregulin 1
  • neuregulin-1 alpha
  • NRG1-alpha

General information

  • Neuregulin-1 (NRG-1) plays important roles in the development and plasticity of the brain, and it has recently been identified as a susceptibility gene for schizophrenia. [1]
  • The neuregulins (NRGs) are a family of four structurally related growth factors that are expressed in the developing and adult brain. [2]
  • NRG-1 is essential for normal heart formation and has been implicated in the development and maintenance of both neurons and glia. [2]
  • NRG-1 plays a role in increasing the genetic risk to positive symptoms of psychosis in a proportion of late onset Alzheimer's disease families. [3]
  • At the cellular level, NRG1 mRNA was abundant in hippocampal and cortical pyramidal neurons and some interneurons, and in cerebellar Purkinje cells and Golgi cells. [1]
  • NRG-1 mRNA was clearly detected in the prefrontal cortex (middle laminae), hippocampal formation (except CA1), cerebellum, oculomotor nucleus, superior colliculus, red nucleus and substantia nigra pars compacta. [1]
  • ErbB2, B3 and B4 are NRG-1 receptors. [1]
  • Neuregulin is a factor required for spermatogonial amplification and differentiation in culture. [4]

Classification

Hormone function

  • development and growth
    • embryogenesis
      • environment adaptation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • neuregulin-family

        Composition

        isoform alpha, chain

        Sequence 
        SGKKPESAA GSQSPALPP RLKEMKSQE 
SAAGSKLVL RCETSSEYS SLRFKWFKN 
GNELNRKNK PQNIKIQKK PGKSELRIN 
KASLADSGE YMCKVISKL GNDSASANI 
TIVESNEII TGMPASTEG AYVSSESPI 
RISVSTEGA NTSSSTSTS TTGTSHLVK 
CAEKEKTFC VNGGECFMV KDLSNPSRY 
LCKCQPGFT GARCTENVP MKVQNQEKA 
EELYQK
        UniProt Q02297-1

        Links to other resources

        UniProt Q02297
        Ensembl ENST00000287840
        KEGG hsa:3084

        • Anatomical structure: hippocampus

        • Anatomical structure: Golgi_cell

        • Anatomical structure: Purkinje_cell

        • Anatomical structure: brain_stem

          • NRG-1 expression was also being present in putative serotonergic neurons of the raphe and dopaminergic neurons of the substantia nigra, indicating that NRG-1 expression is not limited to any particular neurotransmitter-defined class of neurons. [1]

        • Anatomical structure: red_nucleus

        • Anatomical structure: superior_colliculus

        • Anatomical structure: compact_part_of_substantia_nigra

          • NRG-1 expression was also being present in putative serotonergic neurons of the raphe and dopaminergic neurons of the substantia nigra, indicating that NRG-1 expression is not limited to any particular neurotransmitter-defined class of neurons. [1]

        Targets

        CellErbB2ErbB3ErbB4
        No records found.
        Reference