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Details for messenger / hormone: GABA

EndoNet ID: ENH00246

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  • GABA
  • gamma-aminobutyric acid

General information

  • In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. [1]
  • On the presynaptic side, GABAergic inhibition is regulated by 5-HT through the activation of 5-HT2, 5-HT1, and 5-HT3 receptors on GABAergic interneurons. [2]


Hormone function

  • CNS function
    • neurotransmitter

    Chemical classification

    • hormone
      • genome-encoded
        • small-molecule neurotransmitters


      Links to other resources

      • Anatomical structure: Purkinje_cell

        Influenced by:

        • CB1
          in hippocampus
      • Anatomical structure: reticular_part_of_substantia_nigra

        Influenced by:

        • CB1
          in reticular_part_of_substantia_nigra
        • 5-HT-2C
          in substantia_nigra
          • The selective activation of 5-HT2C receptors stimulates non-DA neurons in the substantia nigra pars reticulata (SNr) and mediate an increase in GABA extracellular levels in the SNr. [3]
      • Anatomical structure: cerebellum

        Influenced by:

        • CB1
          in basket_cell
        • CB1
          in cerebellum
      • Anatomical structure: amygdaloid_body

        Influenced by:

        • 5-HT3 receptor
          in amygdaloid_body
          • Activation of presynaptic 5-HT-3 receptors facilitate synaptic GABA release from GABAergic presynaptic nerve terminals in the amygdala. [4]
        • 5-HT-1A
          in amygdaloid_body
          • Activated 5-HT-1A receptors inhibite GABA release in the basolateral amygdala. [5]
      • Anatomical structure: hippocampus

        Influenced by:

        • 5-ht-6R
          in hippocampus
          • The activation of 5-HT6 receptors cause an increase in spontaneous release of GABA. [6]