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Details for messenger / hormone: VEGFC

EndoNet ID: ENH00269

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Synonyms

  • vascular endothelial growth factor-related protein
  • VEGF-C
  • vascular endothelial growth factor c
  • vascular endothelial growth factor related protein
  • Flt4-l
  • VEGFC
  • VRP
  • flt4 ligand

General information

  • Binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors. [1]
  • Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. [1]
  • May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. [1]
  • VEGFC regulates lymphatic angiogenesis. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • PDGF/VEGF growth factor family

      Composition

      Sequence 
      AHYNTEILK SIDNEWRKT QCMPREVCI 
DVGKEFGVA TNTFFKPPC VSVYRCGGC 
CNSEGLQCM NTSTSYLSK TLFEITVPL 
SQGPKPVTI SFANHTSCR CMSKLDVYR 
QVHSIIRR

      Links to other resources

      UniProt P49767
      Ensembl ENST00000280193
      KEGG hsa:7424

        Targets

        CellVascular endothelial growth factor receptor 2VEGFR-3
        bone marrow Present
        Phenotypes
        • angiogenesis
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        Influences
        • ↓ VEGF-165
        microvascularendothelial cell Present
        Influences
        • ↑ von Willebrand factor
        Müllers radial cell of retina Present
        Phenotypes
        • regulation of neural retina development
        sinusoidal endothelial cell Present
        Phenotypes
        • regulation of endothelial cell differentiation
        Reference