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Details for messenger / hormone: neuregulin-2

EndoNet ID: ENH00319

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Synonyms

  • divergent of neuregulin-1
  • neural- and thymus-derived activator for ERBB kinases
  • pro-neuregulin-2, membrane-bound isoform
  • NRG-2
  • divergent of neuregulin 1
  • DON1
  • neural- and thymus-derived activator for the ERBB kinase
  • NTAK
  • NRG2
  • neuregulin-2

General information

  • NRG-2 colocalizes with calbindin in proximal dendrites and soma of Purkinje cells In cerebellum. [1]
  • The neuregulins (NRGs) are a family of four structurally related growth factors that are expressed in the developing and adult brain. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • EGF family

      Composition

      neuregulin-2

      Sequence 
      CYSPSLKSV QDQAYKAPV VVEGKVQGL 
VPAGGSSSN STREPPASG RVALVKVLD 
KWPLRSGGL QREQVISVG SCVPLERNQ 
RYIFFLEPT EQPLVFKTA FAPLDTNGK 
NLKKEVGKI LCTDCATRP KLKKMKSQT 
GQVGEKQSL KCEAAAGNP QPSYRWFKD 
GKELNRSRD IRIKYGNGR KNSRLQFNK 
VKVEDAGEY VCEAENILG KDTVRGRLY 
VNSVSTTLS SWSGHARKC NETAKSYCV 
NGGVCYYIE GINQLSCKC PNGFFGQRC 
LEKLPLRLY MPDPKQKAE ELYQK

      Links to other resources

      UniProt O14511
      Ensembl ENST00000361474
      KEGG hsa:9542

      • Anatomical structure: cerebellum

      • Anatomical structure: brain

        • NRG-2 was identified on the basis of its homology to NRG-1 and, like NRG-1, is expressed predominantly by neurons in the central nervous system. [2]

      • Anatomical structure: hippocampus

        • Don-1 is highly expressed in restricted regions of the cerebellum and hippocampus. [3]

      Targets

      CellErbB3ErbB4
      No records found.
      Reference