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Details for messenger / hormone: inhibin A

EndoNet ID: ENH00332

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Synonyms

  • inhibin A
  • inhibin alpha and beta A

General information

  • Pituitary gonadotropin secretion is regulated by gonadal peptides including inhibin A, an alpha:betaA heterodimer, and inhibin B, an alpha:betaB heterodimer, and follistatin peptides. [1]
  • Inhibits secretion of follitropin by the pituitary gland.
  • Inhibin A is a dimer of alpha and beta-A. [2]

Classification

Hormone function

  • reproduction and sexual differentiation
    • reproduction

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      inhibin alpha (1 times)

      Sequence 
      STPLMSWPW SPSALRLLQ RPPEEPAAH 
ANCHRVALN ISFQELGWE RWIVYPPSF 
IFHYCHGGC GLHIPPNLS LPVPGAPPT 
PAQPYSLLP GAQPCCAAL PGTMRPLHV 
RTTSDGGYS FKYETVPNL LTQHCACI
      UniProt P05111

      inhibin beta A (1 times)

      Sequence 
      GLECDGKVN ICCKKQFFV SFKDIGWND 
WIIAPSGYH ANYCEGECP SHIAGTSGS 
SLSFHSTVI NHYRMRGHS PFANLKSCC 
VPTKLRPMS MLYYDDGQN IIKKDIQNM 
IVEECGCS
      UniProt P08476

      Links to other resources

      • Anatomical structure: granulosa_cell

      • Anatomical structure: placenta

      Targets

      CellACTRIIATGFR-3
      basophil gonadotroph cell of anterior pituitary FSH Present
      Influences
      • ↑ FSH
      • ↑ LH
      cell of endometrium of uterus Present
      Phenotypes
      • cell differentiation
      		Present
      placenta Present
      Reference