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Details for messenger / hormone: persephin

EndoNet ID: ENH00379

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Synonyms

  • PSP
  • PSPN
  • persephin

General information

  • Persephin supports the survival of motor neurons in culture and in vivo after sciatic nerve axotomy and, like GDNF, promotes ureteric bud branching. [1]
  • Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. [2]
  • GFRalpha4 is the ligand-binding subunit required together with RET for PSPN signaling. [3]
  • GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. [4]
  • Persephin, member of the transforming growth factor-beta superfamily and glial cell line-derived neurotrophic factor subfamily, is distributed throughout the nervous system at extremely low levels and is thought to function as a survival factor for midbrain dopaminergic and spinal motor neurons in vivo. [5]
  • Persephin is a neurotrophic factor similar to GDNF and NTN but using additional, or different, receptor components. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Persephin, chain.

      Sequence 
      WGPDARGVP VADGEFSSE QVAKAGGTW 
LGTHRPLAR LRRALSGPC QLWSLTLSV 
AELGLGYAS EEKVIFRYC AGSCPRGAR 
TQHGLALAR LQGQGRAHG GPCCRPTRY 
TDVAFLDDR HRWQRLPQL SAAACGCGG
      UniProt O60542

      Links to other resources

      UniProt O60542
      Ensembl ENST00000245810
      KEGG hsa:5623

      • Anatomical structure: adrenal_cortex

      • Anatomical structure: cerebellum

      • Anatomical structure: spinal_cord

      Targets

      Reference