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Details for messenger / hormone: MIP-1 delta

EndoNet ID: ENH00393

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Synonyms

  • Mrp-2b
  • small-inducible cytokine A15
  • C-C motif chemokine 15
  • MIP-1 delta
  • CCL15
  • macrophage inflammatory protein 5
  • MIP-5
  • chemokine CC-2
  • HCC-2
  • NCC-3
  • leukotactin-1

General information

  • Chemotactic factor that attracts T cells and monocytes, but not neutrophils, eosinophils, or B cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. [1]
  • CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small inducible cytokine A15. [1]
  • Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      small inducible cytokine A15

      Sequence 
      QFINDAETE LMMSKLPLE NPVVLNSFH 
FAADCCTSY ISQSIPCSL MKSYFETSS 
ECSKPGVIF LTKKGRQVC AKPSGPGVQ 
DCMKKLKPY SI

      Links to other resources

      UniProt Q16663
      Ensembl ENST00000394508
      KEGG hsa:6359

      • Anatomical structure: adrenal_gland

      • Anatomical structure: heart

      • Anatomical structure: skeleton_muscle

      Targets

      Reference