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Details for messenger / hormone: HCC-4

EndoNet ID: ENH00407

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Synonyms

  • LMC
  • lymphocyte and monocyte chemoattractant
  • chemokine CC-4
  • liver-expressed chemokine
  • chemokine LEC
  • small-inducible cytokine A16
  • C-C motif chemokine 16
  • HCC-4
  • CCL16
  • hemofiltrate CC chemokine 4
  • ILINCK
  • LCC-1
  • LEC
  • monotactin-1
  • Mtn-1
  • NCC-4
  • SCYA16
  • IL-10-inducible chemokine
  • monotactin 1

General information

  • Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS-and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. [1]
  • Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      Sequence 
      QPKVPEWVN TPSTCCLKY YEKVLPRRL 
VVGYRKALN CHLPAIIFV TKRNREVCT 
NPNDDWVQE YIKDPNLPL LPTRNLSTV 
KIITAKNGQ PQLLNSQ

      Links to other resources

      UniProt O15467
      Ensembl ENST00000293275
      KEGG hsa:6360

      • Anatomical structure: spleen

      • Anatomical structure: thymus

      Targets

      Cell
      No records found.
      Reference