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Details for messenger / hormone: POMC

EndoNet ID: ENH00414

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Synonyms

  • POMC
  • Beta-MSH
  • Gamma-LPH
  • Alpha-MSH
  • adrenocorticotropic hormone
  • Gamma-MSH
  • Beta-LPH
  • pro-opiomelanocortin
  • proopiomelanocortin
  • POC
  • pro-ACTH-endorphin
  • corticotropin-lipotropin

General information

  • Defects in POMC could play a role in the genetic predisposition to obesity.
  • Contains beta-endorphin, corticotropin (Adrenocorticotropic hormone, ACTH), corticotropin-like intermediary peptide (CLIP), lipotropin beta (Beta-LPH), lipotropin gamma (Gamma-LPH), melanotropin alpha (Alpha-MSH), melanotropin beta (Beta-MSH), melanotropin gamma (Gamma-MSH), met-enkephalin, NPP, potential peptide.
  • Expressed in neurons that reduce food intake. [1]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • POMC family

      Links to other resources

      UniProt P01189
      Ensembl ENST00000405623
      KEGG hsa:5443

      • Anatomical structure: arcuate_nucleus_of_hypothalamus

        Influenced by:

        • leptin receptor
          in arcuate_nucleus_of_hypothalamus
        • GHS-R1
          in arcuate_nucleus_of_hypothalamus
          • Ghrelin inhibits POMC neurons of the Hypothalamus

      Targets

      Cell
      No records found.
      Reference