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Details for messenger / hormone: cathepsin L

EndoNet ID: ENH00428

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  • cathepsin L
  • MEP
  • cathepsin L1
  • major excreted protein
  • CTSL

General information

  • MEP is a lysosomal Man- 6-P-containing protease, identical to cathepsin L. [1]
  • Function: Cathepsins B, L and S are ubiquitously expressed in tissues and perform general household functions in protein turnover, although they participate in antigen or major histocompatibility complex (MHC)II invariant chain processing. [2]


Hormone function

  • immune response
    • activation
    • metabolism
      • cell metabolism

      Chemical classification

      Links to other resources

      UniProt P07711
      Ensembl ENST00000343150
      KEGG hsa:1514
      • Anatomical structure: fibroblast

        • Both the synthesis and secretion of MEP are dramatically increased in response to tumor promoters, certain growth factors, and viral transformation. [3]
        • Although the biological function of secreted MEP is not known, the patterno f its regulation by growth factors and transforming agents suggests that it plays some important role in the growth of normal and transformed cells. [1]


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