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Details for messenger / hormone: NO

EndoNet ID: ENH00439

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  • NO
  • nitric oxide
  • nitrogen monoxide
  • endothelium-derived relaxing factor
  • EDRF

General information

  • Insulin has been reported to potentiate the release of NO induced by leptin. [1]
  • NO is made through the deamination of arginine, catalyzed by NO synthase. [2]
  • The effect of NO can occur within seconds. It acts only locally because it has a short half-life: approximaly 5-10 seconds. [2]
  • Macrophage adhesion and accumulation are prevented by NO, which is counterbalanced by angiotensin II. [1]
  • Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. [3]
  • Many nerve cells use NO to signal to their neighbors. [2]
  • NO that is released by autonomic nerves in the penis causes the local blood vessel dilation which is actually responsible for penile erection. [2]
  • NO that is produced by activated endothelial cells informs the underlying smooth muscle cells to relax. That may include the effect of NO on blood vessels. [2]
  • Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. [4]
  • NO is produced as a local mediator by activated macrophages and neutrophils to help them to destroy invading microorganisms. NO is toxic to bacteria and other human pathogens. [2]


Hormone function

  • CNS function
    • neurotransmitter
    • homeostasis
      • cardiovascular control
      • immune response
        • activation

        Chemical classification

        • hormone
          • not genome-encoded

        Links to other resources

        KEGG C00533
        • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

          Influenced by:

          • angiotensin receptor 2
            in adipose_tissue
            • Activation of AT2 results in the production of NO and activation of several phosphatases, such as PTPase and PP2A, resulting in the inactivation of MAPK and changes in potassium and calcium current. [5]
          • insulin receptor
            in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
            • The insulin receptor tyrosine kinase, phosphatidylinositol 3-kinase (PI 3-kinase), and Akt are essential components of insulin-signaling pathways related to production of NO in vascular endothelium [6]


        Cellguanylyl cyclase
        No records found.