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Details for messenger / hormone: laminin gamma-2 chain

EndoNet ID: ENH00469

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Synonyms

  • nicein subunit gamma
  • kalinin subunit gamma
  • epiligrin subunit gamma
  • kalinin/nicein/epiligrin 100 kDa subunit
  • laminin-5 subunit gamma
  • laminin subunit gamma-2
  • laminin gamma-2 chain
  • laminin 5 gamma 2 subunit
  • kalinin 100 kDa subunit
  • nicein 100 kDa subunit
  • epiligrin 100 kDa subunit
  • laminin B2t chain
  • cell-scattering factor 140 kDa subunit
  • CSF 140 kDa subunit
  • large adhesive scatter factor 140 kDa subunit
  • ladsin 140 kDa subunit
  • LAMC2

General information

  • The gamma-2 chain is a subunit of laminin-5 (epiligrin/kalinin/nicein). [1]
  • The gamma-2 chain of laminin-5 is cleaved mainly to a 105-kDa form by astacin-like metalloproteinase families, which include BMP-1 and mammalian tolloid. [2]
  • Increased N-terminal fragments of gamma-2-chains are secreted from alveolar epithelial cells during immediate reepithelization to repair injured lung epithelium. [3]
  • Never joined to the beta-1 chain. [4]
  • The gamma-2 monomer is secreted from some pancreatic carcinoma cells with no production of alpha-3 or beta-3 chain. [3]
  • Epithelial cells regulates their gamma-2-chain expression under the specific stimulation by HGF. [3]
  • HGF contributes to cell migration by assisting cytoplasmic accumulation of laminin gamma-2-chains in invading carcinoma cells. [3]
  • EGF-like domain of gamma-2 chain activates downstream signaling including EGF receptor and ERK1/2 phosphorylation, leading to enhanced cell motility. [3]
  • The cleavage of laminin gamma-2 chain to the 105kDa isoform increases the cell motility activity of laminin-5 but decreases its cell adhesion activity. [2]

Classification

Hormone function

  • homeostasis
    • pulmonary control

    Chemical classification

    Links to other resources

    UniProt Q13753
    Ensembl ENST00000264144
    KEGG hsa:3918

    • Anatomical structure: keratinocyte

    • Anatomical structure: epidermis

    • Anatomical structure: placenta

    • Anatomical structure: skin

    • Anatomical structure: epithelial_cell

    Targets

    Cell
    No records found.
    Reference