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Details for messenger / hormone: sFRP-3

EndoNet ID: ENH00505

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Synonyms

  • sFRP-3
  • frizzled-related protein 1
  • fritz
  • FRZB
  • FIZ
  • FRE
  • FRZB1
  • SFRP3
  • frizzled-related protein
  • secreted frizzled-related protein 3
  • FrzB-1
  • frezzled

General information

  • Regulates chondrocyte maturation and long bone development.
  • Antagonist of Wnt8 signaling.
  • FRZB is involved in morphogenesis of the mammalian skeleton. [1]
  • Members of the Frizzled family of seven-pass transmembrane proteins serve as receptors for Wnt signalling proteins. [2]
  • Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. [3]

Classification

Hormone function

  • development and growth
    • apoptosis
      • embryogenesis

      Chemical classification

      • hormone
        • genome-encoded
          • frizzled family

        Composition

        Secreted frizzled-related protein 3 chain

        Sequence 
        AACEPVRIP LCKSLPWNM TKMPNHLHH 
STQANAILA IEQFEGLLG THCSPDLLF 
FLCAMYAPI CTIDFQHEP IKPCKSVCE 
RARQGCEPI LIKYRHSWP ENLACEELP 
VYDRGVCIS PEAIVTADG ADFPMDSSN 
GNCRGASSE RCKCKPIRA TQKTYFRNN 
YNYVIRAKV KEIKTKCHD VTAVVEVKE 
ILKSSLVNI PRDTVNLYT SSGCLCPPL 
NVNEEYIIM GYEDEERSR LLLVEGSIA 
EKWKDRLGK KVKRWDMKL RHLGLSKSD 
SSNSDSTQS QKSGRNSNP RQARN
        UniProt Q92765

        Links to other resources

        UniProt Q92765
        Ensembl ENST00000295113
        KEGG hsa:2487

        • Anatomical structure: placenta

        • Anatomical structure: pancreas

        • Anatomical structure: spleen

        • Anatomical structure: chondroblast

        • Anatomical structure: heart

        • Anatomical structure: brain

        • Anatomical structure: skeleton_muscle

        • Anatomical structure: kidney

        • Anatomical structure: lung

        • Anatomical structure: cartilage

        Targets

        Cell
        No records found.
        Reference