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Details for messenger / hormone: chordin

EndoNet ID: ENH00509

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Synonyms

  • chordin
  • CHRD

General information

  • The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities. [1]
  • Organizer factor, forebrain development.
  • The organizer factors Chordin and Noggin are required for mouse forebrain development. [2]
  • Chordin is a peptide that binds and antagonizes the action of BMP-2 and BMP-4. It is cleaved by the BMP-1 protease. [3]
  • Bone morphogenetic protein inhibitor.
  • Chordin is underexpressed in ovarian tumors and reduces tumor cell motility. [4]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    Chordin isoform 1 chain

    Sequence 
    AGPEPPVLP IRSEKEPLP VRGAAGCTF 
GGKVYALDE TWHPDLGEP FGVMRCVLC 
ACEAPQWGR RTRGPGRVS CKNIKPECP 
TPACGQPRQ LPGHCCQTC PQERSSSER 
QPSGLSFEY PRDPEHRSY SDRGEPGAE 
ERARGDGHT DFVALLTGP RSQAVARAR 
VSLLRSSLR FSISYRRLD RPTRIRFSD 
SNGSVLFEH PAAPTQDGL VCGVWRAVP 
RLSLRLLRA EQLHVALVT LTHPSGEVW 
GPLIRHRAL AAETFSAIL TLEGPPQQG 
VGGITLLTL SDTEDSLHF LLLFRGLLE 
PRSGGLTQV PLRLQILHQ GQLLRELQA 
NVSAQEPGF AEVLPNLTV QEMDWLVLG 
ELQMALEWA GRPGLRISG HIAARKSCD 
VLQSVLCGA DALIPVQTG AAGSASLTL 
LGNGSLIYQ VQVVGTSSE VVAMTLETK 
PQRRDQRTV LCHMAGLQP GGHTAVGIC 
PGLGARGAH MLLQNELFL NVGTKDFPD 
GELRGHVAA LPYCGHSAR HDTLPVPLA 
GALVLPPVK SQAAGHAWL SLDTHCHLH 
YEVLLAGLG GSEQGTVTA HLLGPPGTP 
GPRRLLKGF YGSEAQGVV KDLEPELLR 
HLAKGMASL LITTKGSPR GELRGQVHI 
ANQCEVGGL RLEAAGAEG VRALGAPDT 
ASAAPPVVP GLPALAPAK PGGPGRPRD 
PNTCFFEGQ QRPHGARWA PNYDPLCSL 
CTCQRRTVI CDPVVCPPP SCPHPVQAP 
DQCCPVCPE KQDVRDLPG LPRSRDPGE 
GCYFDGDRS WRAAGTRWH PVVPPFGLI 
KCAVCTCKG GTGEVHCEK VQCPRLACA 
QPVRVNPTD CCKQCPVGS GAHPQLGDP 
MQADGPRGC RFAGQWFPE SQSWHPSVP 
PFGEMSCIT CRCGAGVPH CERDDCSLP 
LSCGSGKES RCCSRCTAH RRPAPETRT 
DPELEKEAE GS
    UniProt Q9H2X0-1

    Chordin splice isoform 2

    Sequence 
    MPSLPAPPA PLLLLGLLL LGSRPARGA 
GPEPPVLPI RSEKEPLPV RGAAGCTFG 
GKVYALDET WHPDLGEPF GVMRCVLCA 
CEAGP
    UniProt Q9H2X0-2

    Chordin splice isoform 3

    Sequence 
    MPSLPAPPA PLLLLGLLL LGSRPARGA 
GPEPPVLPI RSEKEPLPV RGAAGCTFG 
GKVYALDET WHPDLGEPF GVMRCVLCA 
CEATGTLRP REMK
    UniProt Q9H2X0-3

    chordin isoform 4

    Sequence 
    MPSLPAPPA PLLLLGLLL LGSRPARGA 
GPEPPVLPI RSEKEPLPV RGAAGCTFG 
GKVYALDET WHPDLGEPF GVMRCVLCA 
CEAPQWGRR TRGPGRVSC KNIKPECPT 
PACGQPRQL PGHCCQTCP QERSSSERQ 
PSGLSFEYP RDPEHRSYS DRGEPGAEE 
RARGDGHTD FVALLTGPR SQAVARARV 
SLLRSSLRF SISYRRLDR PTRIRFSDS 
NGSVLFEHP AAPTQDGLV CGVWRAVPR 
LSLRLLRAE QLHVALVTL THPSGEVWG 
PLIRHRALA AETFSAILT LEGPPQQGV 
GGITLLTLS DTEDSLHFL LLFRGLLEP 
RSGDSTPGA ATARTSGQC LSPGTRLC
    UniProt Q9H2X0-4

    chordin splice isoform 5

    Sequence 
    MPSLPAPPA PLLLLGLLL LGSRPARGA 
GPEPPVLPI RSEKEPLPV RGAAGCTFG 
GKVYALDET WHPDLGEPF GVMRCVLCA 
CEAPQWGRR TRGPGRVSC KNIKPECPT 
PACGQPRQL PGHCCQTCP QERSSSERQ 
PSGLSFEYP RDPEHRSYS DRGEPGAEE 
RARGDGHTD FVALLTGPR SQAVARARV 
SLLRSSLRF SISYRRLDR PTRIRFSDS 
NGSVLFEHP AAPTQDGLV CGVWRAVPR 
LSLRLLRAE QLHVALVTL THPSGEVWG 
PLIRHRALA AETFSAILT LEGPPQQGV 
GGITLLTLS DTEDSLHFL LLFRGLLEP 
RSGGLTQVP LRLQILHQG QLLRELQAN 
VSAQEPGFA EVLPNLTVQ EMDWLVLGE 
LQMALEWAG RPGLRISGH IAARKSCDV 
LQSVLCGAD ALIPVQTGA AGSASLTLL 
GNGSLIYQA VGICPGLGA RGAHMLLQN 
ELFLNVGTK DFPDGELRG HVAALPYCG 
HSARHDTLP VPLAGALVL PPVKSQAAG 
HAWLSLDTH CHLHYEVLL AGLGGSEQG 
TVTAHLLGP PGTPGPRRL LKGFYGSEA 
QGVVKDLEP ELLRHLAKG MASLLITTK 
GSPRGELRG QVHIANQCE VGGLRLEAA 
GAEGVRALG APDTASAAP PVVPGLPAL 
APAKPGGPG RPRDPNTCF FEGQQRPHG 
ARWAPNYDP LCSLCTCQR RTVICDPVV 
CPPPSCPHP VQAPDQCCP VCPEKQDVR 
DLPGLPRSR DPGEGCYFD GDRSWRAAG 
TRWHPVVPP FGLIKCAVC TCKGGTGEV 
HCEKVQCPR LACAQPVRV NPTDCCKQC 
PVGSGAHPQ LGDPMQADG PRGCRFAGQ 
WFPESQSWH PSVPPFGEM SCITCRCGA 
GVPHCERDD CSLPLSCGS GKESRCCSR 
CTAHRRPAP ETRTDPELE KEAEGS
    UniProt Q9H2X0-5

    Links to other resources

    UniProt Q9H2X0
    Ensembl ENST00000204604
    KEGG hsa:8646

    • Anatomical structure: cerebellum

    Targets

    Cell
    No records found.
    Reference