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Details for messenger / hormone: VEGFD

EndoNet ID: ENH00516

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Synonyms

  • c-fos-induced growth factor
  • vascular endothelial growth factor D
  • VEGFD
  • VEGF-D
  • FIGF

General information

  • VEGF-D has been shown to be responsible for proliferation of ECs, and it shows angiogenic properties in vitro and in vivo. [1]
  • VEGFD regulates lymphatic angiogenesis. [2]
  • Similar to VEGF-C, it also shows lymphangiogenic potential. [1]
  • Nonetheless, VEGF-D may induce lymphatic vessel growth in adult life in response to pathological conditions. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • PDGF/VEGF growth factor family

      Composition

      Sequence 
      FAATFYDIE TLKVIDEEW QRTQCSPRE 
TCVEVASEL GKSTNTFFK PPCVNVFRC 
GGCCNEESL ICMNTSTSY ISKQLFEIS 
VPLTSVPEL VPVKVANHT GCKCLPTAP 
RHPYSIIRR

      Links to other resources

      UniProt O43915
      Ensembl ENST00000297904
      KEGG hsa:2277

        Targets

        CellVascular endothelial growth factor receptor 2VEGFR-3
        bone marrow Present
        Phenotypes
        • angiogenesis
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        Influences
        • ↓ VEGF-165
        microvascularendothelial cell Present
        Influences
        • ↑ von Willebrand factor
        Müllers radial cell of retina Present
        Phenotypes
        • regulation of neural retina development
        sinusoidal endothelial cell Present
        Phenotypes
        • regulation of endothelial cell differentiation
        Reference