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Details for messenger / hormone: APOA5

EndoNet ID: ENH00547

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Synonyms

  • ApoA-V
  • APOA5
  • apolipoprotein A5
  • apolipoprotein A-V
  • regeneration-associated protein 3
  • RAP3

General information

  • APOAV is an important determinant of plasma TG and lipoprotein cholesterol, and is potentially a risk factor for cardiovascular disease. [1]
  • APOA-V plays a important role in modulating high-density lipoprotein maturation and cholesterol metabolism. [2]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • apoproteins

      Composition

      Sequence 
      RKGFWDYFS QTSGDKGRV EQIHQQKMA 
REPATLKDS LEQDLNNMN KFLEKLRPL 
SGSEAPRLP QDPVGMRRQ LQEELEEVK 
ARLQPYMAE AHELVGWNL EGLRQQLKP 
YTMDLMEQV ALRVQELQE QLRVVGEDT 
KAQLLGGVD EAWALLQGL QSRVVHHTG 
RFKELFHPY AESLVSGIG RHVQELHRS 
VAPHAPASP ARLSRCVQV LSRKLTLKA 
KALHARIQQ NLDQLREEL SRAFAGTGT 
EEGAGPDPQ MLSEEVRQR LQAFRQDTY 
LQIAAFTRA IDQETEEVQ QQLAPPPPG 
HSAFAPEFQ QTDSGKVLS KLQARLDDL 
WEDITHSLH DQGHSHLGD P

      Links to other resources

      UniProt Q6Q788
      Ensembl ENST00000227665
      KEGG hsa:116519

      • Anatomical structure: hepatocyte

        • APOA5 is expressed in human hepatoma HepG2 cells with levels comparable with human primary hepatocytes. [3]

        Influenced by:

        • THRA1
          in hepatocyte
          • Treatment with T3 significantly increased APOA5 mRNA levels at 6 h, and a 2-fold induction was achieved after 24 h of T3 addition. [3]
        • THRB1
          in hepatocyte
          • T3-activated TRbeta1 enhanced the activity of APOA5 DR4-driven promoter constructs. [3]
          • Treatment with T3 significantly increased APOA5 mRNA levels at 6 h, and a 2-fold induction was achieved after 24 h of T3 addition. [3]
        • bile acid receptor
          in hepatocyte
          • Bile acids induce human apoAV promoter activity via FXR. [4]
        • LXR-alpha
          in hepatocyte
          • Co-transfection of SREBP-1c downregulates APOA5 promoter activity. [5]
        • PPAR-alpha
          in hepatocyte
          • Overexpression of PPAR-alpha enhances the activity of the human ApoA5 gene promoter. [4]

      Targets

      Cell
      No records found.
      Reference