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Details for messenger / hormone: apo B-48

EndoNet ID: ENH00549

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Synonyms

  • ApoB-48
  • apolipoprotein B-100
  • apo B-48
  • apolipoprotein B-48
  • ApoB48
  • apo B48
  • apolipoproteinB-48

General information

  • Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. [1]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • apoproteins

      Composition

      apolipoprotein B-48

      Sequence 
      EEEMLENVS LVCPKDATR FKHLRKYTY 
NYEAESSSG VPGTADSRS ATRINCKVE 
LEVPQLCSF ILKTSQCTL KEVYGFNPE 
GKALLKKTK NSEEFAAAM SRYELKLAI 
PEGKQVFLY PEKDEPTYI LNIKRGIIS 
ALLVPPETE EAKQVLFLD TVYGNCSTH 
FTVKTRKGN VATEISTER DLGQCDRFK 
PIRTGISPL ALIKGMTRP LSTLISSSQ 
SCQYTLDAK RKHVAEAIC KEQHLFLPF 
SYNNKYGMV AQVTQTLKL EDTPKINSR 
FFGEGTKKM GLAFESTKS TSPPKQAEA 
VLKTLQELK KLTISEQNI QRANLFNKL 
VTELRGLSD EAVTSLLPQ LIEVSSPIT 
LQALVQCGQ PQCSTHILQ WLKRVHANP 
LLIDVVTYL VALIPEPSA QQLREIFNM 
ARDQRSRAT LYALSHAVN NYHKTNPTG 
TQELLDIAN YLMEQIQDD CTGDEDYTY 
LILRVIGNM GQTMEQLTP ELKSSILKC 
VQSTKPSLM IQKAAIQAL RKMEPKDKD 
QEVLLQTFL DDASPGDKR LAAYLMLMR 
SPSQADINK IVQILPWEQ NEQVKNFVA 
SHIANILNS EELDIQDLK KLVKEALKE 
SQLPTVMDF RKFSRNYQL YKSVSLPSL 
DPASAKIEG NLIFDPNNY LPKESMLKT 
TLTAFGFAS ADLIEIGLE GKGFEPTLE 
ALFGKQGFF PDSVNKALY WVNGQVPDG 
VSKVLVDHF GYTKDDKHE QDMVNGIML 
SVEKLIKDL KSKEVPEAR AYLRILGEE 
LGFASLHDL QLLGKLLLM GARTLQGIP 
QMIGEVIRK GSKNDFFLH YIFMENAFE 
LPTGAGLQL QISSSGVIA PGAKAGVKL 
EVANMQAEL VAKPSVSVE FVTNMGIII 
PDFARSGVQ MNTNFFHES GLEAHVALK 
AGKLKFIIP SPKRPVKLL SGGNTLHLV 
STTKTEVIP PLIENRQSW SVCKQVFPG 
LNYCTSGAY SNASSTDSA SYYPLTGDT 
RLELELRPT GEIEQYSVS ATYELQRED 
RALVDTLKF VTQAEGAKQ TEATMTFKY 
NRQSMTLSS EVQIPDFDV DLGTILRVN 
DESTEGKTS YRLTLDIQN KKITEVALM 
GHLSCDTKE ERKIKGVIS IPRLQAEAR 
SEILAHWSP AKLLLQMDS SATAYGSTV 
SKRVAWHYD EEKIEFEWN TGTNVDTKK 
MTSNFPVDL SDYPKSLHM YANRLLDHR 
VPETDMTFR HVGSKLIVA MSSWLQKAS 
GSLPYTQTL QDHLNSLKE FNLQNMGLP 
DFHIPENLF LKSDGRVKY TLNKNSLKI 
EIPLPFGGK SSRDLKMLE TVRTPALHF 
KSVGFHLPS REFQVPTFT IPKLYQLQV 
PLLGVLDLS TNVYSNLYN WSASYSGGN 
TSTDHFSLR ARYHMKADS VVDLLSYNV 
QGSGETTYD HKNTFTLSC DGSLRHKFL 
DSNIKFSHV EKLGNNPVS KGLLIFDAS 
SSWGPQMSA SVHLDSKKK QHLFVKEVK 
IDGQFRVSS FYAKGTYGL SCQRDPNTG 
RLNGESNLR FNSSYLQGT NQITGRYED 
GTLSLTSTS DLQSGIIKN TASLKYENY 
ELTLKSDTN GKYKNFATS NKMDMTFSK 
QNALLRSEY QADYESLRF FSLLSGSLN 
SHGLELNAD ILGTDKINS GAHKATLRI 
GQDGISTSA TTNLKCSLL VLENELNAE 
LGLSGASMK LTTNGRFRE HNAKFSLDG 
KAALTELSL GSAYQAMIL GVDSKNIFN 
FKVSQEGLK LSNDMMGSY AEMKFDHTN 
SLNIAGLSL DFSSKLDNI YSSDKFYKQ 
TVNLQLQPY SLVTTLNSD LKYNALDLT 
NNGKLRLEP LKLHVAGNL KGAYQNNEI 
KHIYAISSA ALSASYKAD TVAKVQGVE 
FSHRLNTDI AGLASAIDM STNYNSDSL 
HFSNVFRSV MAPFTMTID AHTNGNGKL 
ALWGEHTGQ LYSKFLLKA EPLAFTFSH 
DYKGSTSHH LVSRKSISA ALEHKVSAL 
LTPAEQTGT WKLKTQFNN NEYSQDLDA 
YNTKDKIGV ELTGRTLAD LTLLDSPIK 
VPLLLSEPI NIIDALEMR DAVEKPQEF 
TIVAFVKYD KNQDVHSIN LPFFETLQE 
YFERNRQTI IVVVENVQR NLKHINIDQ 
FVRKYRAAL GKLPQQAND YLNSFNWER 
QVSHAKEKL TALTKKYRI TENDIQIAL 
DDAKINFNE KLSQLQTYM I

      Links to other resources

      UniProt P04114
      Ensembl ENST00000233242
      KEGG hsa:338

      • Anatomical structure: hepatocyte

        Influenced by:

        • LDL-R
          in hepatocyte
          • Apolipoprotein B (apoB) is required for the hepatic assembly and secretion of very low density lipoprotein (VLDL). The LDL receptor (LDLR) promotes post-translational degradation of apoB and thereby reduces VLDL particle secretion. [2]
          • LDLR directs apoB to degradation in a post-ER compartment. Furthermore, the reuptake mechanism of degradation occurs via internalization of apoB through a constitutive endocytic pathway and apoE through a ligand-dependent pathway. [2]
        • Sterol O-acyltransferase 1
          in hepatocyte
          • Cholesteryl esters play an important role in regulating the assembly and secretion of apoB-containing lipoproteins. [3]

      Targets

      Cellthrombospondin receptor
      adipose tissue Present
      Phenotypes
      • transport of long-chain fatty acids
      blood vessel Present
      bone marrow Present
      cell of endometrium of uterus Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • negative regulation of angiogenesis
      cytotrophoblast Present
      fat cell Present
      Phenotypes
      • transport of long-chain fatty acids
      monocyte Present
      Phenotypes
      • positive regulation of macrophage derived foam cell
      placenta Present
      platelet Present
      Phenotypes
      • regulation of cell adhesion
      skeleton muscle Present
      Phenotypes
      • lipid homeostasis
      Reference