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Details for messenger / hormone: WISP-2

EndoNet ID: ENH00570

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Synonyms

  • CCN family member 5
  • WNT1-inducible-signaling pathway protein 2
  • WISP-2
  • WNT1-inducible signaling pathway protein 2
  • connective tissue growth factor-like protein
  • CTGF-L
  • connective tissue growth factor-related protein 58
  • CCN5
  • CT58
  • CTGFL
  • WNT-1 induced secreted protein-2

General information

  • WISP-2 is an estrogen-inducible gene in human breast cancer cells. [1]
  • WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. [2]
  • WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells. [1]

Classification

Hormone function

  • development and growth
    • cancer / metastasis
      • growth stimulation

      Chemical classification

      Composition

      WNT1-inducible signaling pathway protein 2

      Sequence 
      QLCPTPCTC PWPPPRCPL GVPLVLDGC 
GCCRVCARR LGEPCDQLH VCDASQGLV 
CQPGAGPGG RGALCLLAE DDSSCEVNG 
RLYREGETF QPHCSIRCR CEDGGFTCV 
PLCSEDVRL PSWDCPHPR RVEVLGKCC 
PEWVCGQGG GLGTQPLPA QGPQFSGLV 
SSLPPGVPC PEWSTAWGP CSTTCGLGM 
ATRVSNQNR FCRLETQRR LCLSRPCPP 
SRGRSPQNS AF
      UniProt O76076

      Links to other resources

      UniProt O76076
      Ensembl ENST00000372868
      KEGG hsa:8839

      • Anatomical structure: osteoblast

      • Anatomical structure: fibroblast

      • Anatomical structure: ovary

      • Anatomical structure: testis

      • Anatomical structure: heart

      Targets

      Cell
      No records found.
      Reference