Status
Please wait ...

Details for messenger / hormone: CYR61

EndoNet ID: ENH00582

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • CCN family member 1
  • cysteine-rich angiogenic inducer 61
  • IGFBP10
  • GIG1
  • insulin-like growth factor-binding protein 10
  • protein GIG1
  • cysteine-rich, angiogenic inducer, 61
  • CYR61
  • CCN1
  • GIGI-protein
  • protein CYR61

General information

  • Two immediate early gene-encoded members of the family of the Cyr61/CTGF/Nov proteins referred to as cysteine-rich protein 61 (Cyr61/CCN1) and connective tissue growth factor (CTGF/CCN2), are highly expressed in several mechanical stress-related pathologies, which result from either increased externally applied or internally generated forces by the actin cytoskeleton. [1]
  • CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. [2]
  • Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa x tissue factor-induced signal transduction. [3]
  • The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells. [4]
  • CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. [5]
  • CCN1 induces fibroblast apoptosis through its adhesion receptors, integrin alpha6beta1 and the heparan sulfate proteoglycan (HSPG) syndecan-4, triggering the transcription-independent p53 activation of Bax to render cytochrome c release and activation of caspase-9 and -3. [6]
  • CYR61 is a member of an emerging family of growth regulators that includes the human connective tissue growth factor and the chicken protooncoprotein Nov. [7]
  • Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. [8]
  • The adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans. [9]
  • Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. [10]
  • Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway. [11]
  • Cyr61 is a member of the CCN family of growth factors; these proteins are secreted and can act as ligands of distinct integrins. [8]
  • CYR61 is a secreted, cysteine-rich heparin-binding protein that associates with the extracellular matrix and cell surface. [7]
  • Cyr61 plays a functional role in breast cancer progression, possibly through its interactions with the alpha(v)beta3 receptor. [12]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • CCN family

      Composition

      Protein CYR61, chain.

      Sequence 
      TCPAACHCP LEAPKCAPG VGLVRDGCG 
CCKVCAKQL NEDCSKTQP CDHTKGLEC 
NFGASSTAL KGICRAQSE GRPCEYNSR 
IYQNGESFQ PNCKHQCTC IDGAVGCIP 
LCPQELSLP NLGCPNPRL VKVTGQCCE 
EWVCDEDSI KDPMEDQDG LLGKELGFD 
ASEVELTRN NELIAVGKG SSLKRLPVF 
GMEPRILYN PLQGQKCIV QTTSWSQCS 
KTCGTGIST RVTNDNPEC RLVKETRIC 
EVRPCGQPV YSSLKKGKK CSKTKKSPE 
PVRFTYAGC LSVKKYRPK YCGSCVDGR 
CCTPQLTRT VKMRFRCED GETFSKNVM 
MIQSCKCNY NCPHANEAA FPFYRLFND 
IHKFRD
      UniProt O00622

      Links to other resources

      UniProt O00622
      Ensembl ENSG00000142871
      KEGG hsa:3491

      • Anatomical structure: brain

      • Anatomical structure: cerebellar_cortex

      • Anatomical structure: heart

      • Anatomical structure: hippocampus

      • Anatomical structure: lung

      • Anatomical structure: pancreas

      • Anatomical structure: placenta

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: skin

      • Anatomical structure: spinal_cord

      • Anatomical structure: fibroblast

      Targets

      Cellintegrin alpha-6/beta-1integrin alpha-V/beta-5integrin alphaV/beta3
      endothelial cell Present
      Phenotypes
      • endothelial cell adhesion
      • positive regulation of endothelial cell migration
      kidney Present
      oligodendrocyte Present
      Reference