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Details for messenger / hormone: LTB4

EndoNet ID: ENH00586

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Synonyms

  • LTB4
  • leukotriene B4
  • 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid

General information

  • Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. [1]
  • LTB4 plays a physiological role in regulating dendritic cell trafficking during induction of immune responses. [2]
  • Leukotriene B(4) is a potent chemoattractant known to be involved mainly in inflammation, immune responses, and host defense against infection. [3]
  • In humans,the antimicrobial peptide LL-37 enhances LTB4-induced phagocytosis. The positive feedback circuits between LL-37 and LTB4 stimulate the release of these mediators with the potential for synergistic bioactions and enhanced immune responses. [4]
  • LTB4 induces monocyte chemoattractant protein-1 production in primary human monocytes. [5]
  • Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. [3]
  • LTB4 plays an important role in the fight against murine cytomegalovirus infection in vivo. [6]
  • Synthesized by the enzyme 5-lipoxygenase (5-LO), and its activating protein (FLAP).
  • LTB4 plays a novel role in the augmentation of neutrophil phagocytosis. [7]
  • LTB4 mediates the inflammatory effects of toxin A via activation of TRPV1 receptors. [8]
  • The LTB4-BLT1 pathway is an important target for the treatment of bronchial asthma. [9]
  • Cytochrome p450 (CYP) 4Fs metabolize leukotriene B(4) and other inflammatory mediators in the arachidonic acid cascade. [10]
  • LTB4 causes the release of potent antimicrobial agents from PMN (polymorphonuclear leukocytes) in vitro as well as in vivo. [11]
  • LTB4 stimulates immunoreactive interleukin-6 production and that the underlying mechanisms involve both increased IL-6 gene transcription and message stabilization. [12]
  • Leukotriene B(4) promotes reactive oxidant generation and leukocyte adherence during acute hypoxia. [13]
  • LTB4 plays a significant role in mechanical hyperalgesia induced by autologous nucleus pulposus. [14]
  • LTB4 and LXA4(lipoxin A4) regulate the proliferation and differentiation of neural stem cells. [15]
  • important role in a variety of pathological conditions including rheumatoid arthritis (RA), psoriasis, and inflammatory bowel disease [16]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • leukotrienes

      Composition

      Links to other resources

      KEGG C02165
      LIPID MAPS LMFA03020001
      LipidBank XPR3101

      • Anatomical structure: leukocyte

      • Anatomical structure: mast_cell

      Targets

      CellCysLTR1LTB4-R1LTB4-R2PPAR-alpha
      adipose tissue Present
      beta cell of islet of Langerhans Present
      Influences
      • ↑ insulin
      brain Present
      colon Present
      digestive system Present
      G cell Present
      Influences
      • ↑ gastrin
      heart Present
      		Present
      		Present
      hepatocyte Present
      Influences
      • ↑ APOA5
      • ↑ apo B-100
      kidney Present
      leukocyte Present
      		Present
      lung Present
      lymphoid tissue Present
      pancreas Present
      peripheral blood leukocytes Present
      placenta Present
      skeleton muscle Present
      		Present
      small intestine Present
      spleen Present
      Reference