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Details for messenger / hormone: LTC4

EndoNet ID: ENH00589

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Synonyms

  • LTC4
  • leukotriene C4
  • cysteinyl leukotriene C4
  • 5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid

General information

  • LTC4 acts as a potential growth factor for lung fibroblasts. [1]
  • LTC4 is not a mediator of hypoxic pulmonary vasoconstriction. [2]
  • LTC4 is released into the airways and thought to be central mediators of the asthmatic response during an asthmatic episode. [3]
  • LTC4 is dependent on or signal through STAT6 (signal transducer and activator of transcription 6) to increase airway responsiveness. [3]
  • TC4 acts as a potential growth factor for lung fibroblasts. [4]
  • LTC4 regulates parasite clearance by mouse peritoneal macrophages by increasing uptake and intracellular destruction. [5]

Classification

Hormone function

  • homeostasis
    • pulmonary control
    • development and growth
      • growth stimulation

      Chemical classification

      • hormone
        • not genome-encoded
          • eicosanoids/fatty acid derivatives
            • leukotrienes

        Composition

        Links to other resources

        KEGG C02166
        LIPID MAPS LMFA03020003
        LipidBank XPR3201

          Targets

          CellCysLTR1CysLTR2
          adrenal gland Present
          colon Present
          heart Present
          		Present
          lung Present
          		Present
          pancreas Present
          peripheral blood leukocytes Present
          		Present
          placenta Present
          		Present
          small intestine Present
          smooth muscle Present
          spleen Present
          		Present
          Reference