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Details for messenger / hormone: RFRP-1

EndoNet ID: ENH00596

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Synonyms

  • neuropeptide RFRP-3
  • neuropeptide VF
  • FMRFamide-related peptides
  • RFRP-1
  • neuropeptide NPSF
  • neuropeptide RFRP-1
  • FaRP1
  • RFamide-related peptide 1

General information

  • The RFamide-related peptide gene, C7orf9, which encodes a precursor protein for at least two small neuropeptides, referred to as NPSF (alias RFRP-1) and NPVF (alias RFRP-3), is abundantly expressed in the human retina. [1]
  • RFamide-related peptides are potentially involved in pain regulation through a hypothalamo-medullary projection system, and possibly via action on neuropeptide FF 2 receptors. [2]
  • Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus. [3]
  • FMRFamide-related peptide.
  • FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. [4]

Classification

Hormone function

  • CNS function
    • pain

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • FaRP family

      Composition

      Sequence 
      SLNFEELKD WGPKNVIKM STPAVNKMP 
HSFANLPLR F

      Links to other resources

      UniProt Q9HCQ7
      Ensembl ENST00000222674
      KEGG hsa:64111

      • Anatomical structure: retina

      • Anatomical structure: hypothalamus

        • Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus. [3]

        Influenced by:

        • melatonin 1 receptor
          in hypothalamus
          • Melatonin stimulates the expression and release of GnIH via melatonin receptors expressed by GnIH neurons. [5]

      Targets

      CellNPFF-R1
      hypothalamus Present
      Influences
      • ↓ GnRH-I
      pituitary gland of diencephalon Present
      Influences
      • ↓ FSH
      • ↓ LH
      Reference