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Details for messenger / hormone: neudesin

EndoNet ID: ENH00639

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Synonyms

  • cell immortalization-related protein 2
  • SPUF
  • neudesin
  • neuron-derived neurotrophic factor
  • secreted protein of unknown function
  • NENF
  • SCIRP10
  • CIR2
  • cell immortalization-related 2

General information

  • Neudesin activates the mitogen-activated protein (MAP) and phosphatidylinositol-3 (PI-3) kinase pathways. [1]
  • Neudesin is an extracellular heme-binding protein and that its neurotrophic activity is dependent on the binding of heme to its cytochrome b(5)-like heme/steroid-binding domain. [2]
  • Neudesin encodes a secreted signal with neurotrophic activity in neurons. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Composition

    Neudesin (chain).

    Sequence 
    GQTPRPAER GPPVRLFTE EELARYGGE 
EEDQPIYLA VKGVVFDVT SGKEFYGRG 
APYNALTGK DSTRGVAKM SLDPADLTH 
DTTGLTAKE LEALDEVFT KVYKAKYPI 
VGYTARRIL NEDGSPNLD FKPEDQPHF 
DIKDEF
    UniProt Q9UMX5

    Links to other resources

    UniProt Q9UMX5
    Ensembl ENST00000366988
    KEGG hsa:29937

    • Anatomical structure: brain

    Targets

    Cell
    No records found.
    Reference