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Details for messenger / hormone: beta-endorphin

EndoNet ID: ENH00646

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Synonyms

  • Beta-MSH
  • Gamma-LPH
  • Beta-LPH
  • Alpha-MSH
  • adrenocorticotropic hormone
  • Gamma-MSH
  • Corticotropin-lipotropin
  • Pro-opiomelanocortin
  • beta-endorphin
  • beta-END

General information

  • The C-terminal tetrapeptide of beta-endorphin (MPF) enhances lymphocyte proliferative responses. [1]
  • Beta-endorphin enhances polyamine transport in human lymphocytes. [2]
  • Beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opiate receptor expression in human epidermis. [3]
  • Beta-END is a modifier of hair follicle melanocytes phenotype via its ability to upregulate melanogenesis, dendricity, and proliferation. [4]
  • Beta-endorphin has an inhibitory effect on IL-8 production by decidual cells, and this effect is mediated via opioid receptors and is calcium-dependent. [5]
  • Endogenous opiates, such as beta-endorphin, inhibit the release of luteinizing hormone (LH) release in the pituitary gland. [6]

Classification

Hormone function

  • homeostasis
    • further hormone secretion
    • development and growth
      • growth stimulation

      Chemical classification

      • hormone
        • genome-encoded
          • POMC family

        Composition

        Sequence 
        YGGFMTSEK SQTPLVTLF KNAIIKNAY 
KKGE

        Links to other resources

        UniProt P01189
        Ensembl ENST00000405623
        KEGG hsa:5443

        • Anatomical structure: gonadotropin_releasing_hormone_neuron

        Targets

        CellMOR-1
        No records found.
        Reference