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Details for messenger / hormone: ectodysplasin-A

EndoNet ID: ENH00661

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Synonyms

  • ED1
  • ectodysplasin-A
  • EDA
  • anhidrotic ectodermal dysplasia 1
  • ectodysplasin A
  • ectodermal dysplasia protein
  • EDA protein
  • ectodysplasin-A, secreted form

General information

  • Anhidrotic ectodermal dysplasia (EDA) is an X-linked recessive disorder which affects ectodermal structures. [1]
  • Secreted form is produced through processing by furin. [2]
  • EDA splice isoforms EDA-A1 and EDA-A2 belong to the TNF ligand family and regulate skin appendage formation by activating NF-kappa B- and JNK- promoted transcription. [3]
  • Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. [4]
  • Wnt signaling controls EDA gene expression, but ectodysplasin-A does not feedback on the Wnt pathway. [5]
  • EDA-A1 specifically binds EDAR, EDA-A2 specifically binds XEDAR. [6]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    Ectodysplasin-A, secreted form.

    Sequence 
    SKSNEGADG PVKNKKKGK KAGPPGPNG 
PPGPPGPPG PQGPPGIPG IPGIPGTTV 
MGPPGPPGP PGPQGPPGL QGPSGAADK 
AGTRENQPA VVHLQGQGS AIQVKNDLS 
GGVLNDWSR ITMNPKVFK LHPRSGELE 
VLVDGTYFI YSQVEVYYI NFTDFASYE 
VVVDEKPFL QCTRSIETG KTNYNTCYT 
AGVCLLKAR QKIAVKMVH ADISINMSK 
HTTFFGAIR LGEAPAS
    UniProt Q92838

    Links to other resources

    UniProt Q92838
    Ensembl ENST00000374553
    KEGG hsa:1896

    • Anatomical structure: ectoderm

    • Anatomical structure: keratinocyte

    • Anatomical structure: hair_follicle

    • Anatomical structure: sweat_glands

    Targets

    Cell
    No records found.
    Reference