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Details for messenger / hormone: Cystatin-C

EndoNet ID: ENH00665

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Synonyms

  • Cystatin-3
  • Cystatin-C
  • CST3
  • cystatin C
  • AD8
  • cystatin 3
  • gamma-trace
  • neuroendocrine basic polypeptide
  • post-gamma-globulin

General information

  • As a potent inhibitor of lysosomal cysteine proteases, cystatin C very efficiently inhibits in vitro tumor cell-mediated degradation and invasion of an extracellular matrix. [1]
  • Cystatin C acts as a TGF-beta receptor antagonist. This could constitute a negative feedback loop that inhibits TGF-beta signaling. [1]
  • Most cells secrete cystatin C. [1]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    Composition

    Cystatin C.

    Sequence 
    SSPGKPPRL VGGPMDASV EEEGVRRAL 
DFAVGEYNK ASNDMYHSR ALQVVRARK 
QIVAGVNYF LDVELGRTT CTKTQPNLD 
NCPFHDQPH LKRKAFCSF QIYAVPWQG 
TMTLSKSTC QDA
    UniProt P01034

    Links to other resources

    UniProt P01034
    Ensembl ENST00000398411
    KEGG hsa:1471

    • Anatomical structure: astrocyte

    • Anatomical structure: brain

    • Anatomical structure: thymus

    • Anatomical structure: ovary

    • Anatomical structure: gallbladder

    • Anatomical structure: placenta

    • Anatomical structure: small_intestine

    • Anatomical structure: stomach

    • Anatomical structure: testis

    • Anatomical structure: prostate

    Targets

    Cellcystein proteases
    parts of human body Present
    Phenotypes
    • amyloidosis type 6
    Reference