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Details for messenger / hormone: CST8

EndoNet ID: ENH00666

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Synonyms

  • Cystatin-8
  • CST8
  • cystatin-related epididymal specific
  • cystatin 8
  • CRES
  • cystatin-related epididymal spermatogenic
  • cystatin-related epididymal spermatogenic protein
  • CST-8

General information

  • CRES does not inhibit cysteine proteases but rather inhibits the serine protease prohormone convertase 2, an enzyme with roles in proprotein processing in the neuroendocrine system. [1]
  • Cres gene is preferentialy expressed in postmeiotic germ cells, the proximal caput epididymidis, and anterior pituitary gonadotrophs. [2]
  • CRES is a new cross-class inhibitor that may regulate PC2 of PC2-like proteases and suggests a role for CRES in the regulation of prohormone and proprotein processing. [2]
  • CRES, testatin, and cystatin T are secretory proteins of a similar molecular weight as the archetypal cystatin C and contain the four conserved cysteine residues that direct tertiary structure, thus predicting the proteins conformationally resemble the family 2 cystatins. [3]
  • Cres is expressed in the gonadotropes and colocalizes with LHbeta suggesting a role in the regulation of gonadotrope secretion. [1]
  • The presence of CRES protein in the sperm acrosome suggests that CRES may play a role in the regulation of intraacrosomal protein processing or may be involved in fertilization. [4]

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    Composition

    CST8

    Sequence 
    KDPKKNETG VLRKLKPVN ASNANVKQC 
LWFAMQEYN KESEDKYVF LVVKTLQAQ 
LQVTNLLEY LIDVEIARS DCRKPLSTN 
EICAIQENS KLKRKLSCS FLVGALPWN 
GEFTVMEKK CEDA
    UniProt O60676

    Links to other resources

    UniProt O60676
    Ensembl ENST00000246012
    KEGG hsa:10047

    • Anatomical structure: epididymis

    • Anatomical structure: testis

    Targets

    Cell
    No records found.
    Reference