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Details for messenger / hormone: PD-L1

EndoNet ID: ENH00669

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Synonyms

  • PDL1
  • programmed cell death 1 ligand 1
  • PD-L1
  • programmed death ligand 1
  • PDCD1 ligand 1
  • B7 homolog 1
  • B7-H1
  • CD274 antigen
  • B7H1
  • CD274
  • PDCD1L1
  • PDCD1LG1
  • programmed death ligand 1 isoform 3

General information

  • Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. [1]
  • B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. [2]
  • Cancer cell expression of the B7-H1 glycoprotein has been implicated as a potent inhibitor of T cell-mediated antitumoral immunity. [3]
  • IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells. [4]
  • B7-H1 expression is augmented in cells of HIV patients; increased IL-10 production in these patients is largely induced by B7-H1-expressing CD14(+) cells. [5]
  • B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. [6]
  • B7-H1 is constitutively expressed on monocytes and differentially matured dendritic cells, but not on B cells. [7]
  • B7-H1 and B7-DC play a role in virus-associated immune responses in the airways. [8]
  • Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. [9]
  • PD-L1 is expressed by human renal tubular epithelial cells and suppresses T cell cytokine synthesis. [10]
  • B7 family member.
  • Interferon-beta enhances monocyte and dendritic cell expression of B7-H1, a strong inhibitor of autologous T-cell activation. [7]

Classification

Hormone function

  • development and growth
    • apoptosis
    • immune response

    Chemical classification

    • hormone
      • genome-encoded
        • immunoglobulin superfamily

      Composition

      PD-L1I

      Sequence 
      FTVTVPKDL YVVEYGSNM TIECKFPVE 
KQLDLAALI VYWEMEDKN IIQFVHGEE 
DLKVQHSSY RQRARLLKD QLSLGNAAL 
QITDVKLQD AGVYRCMIS YGGADYKRI 
TVKVNAPYN KINQRILVV DPVTSEHEL 
TCQAEGYPK AEVIWTSSD HQVLSGKTT 
TTNSKREEK LFNVTSTLR INTTTNEIF 
YCTFRRLDP EENHTAELV IPELPLAHP 
PNERTHLVI LGAILLCLG VALTFIFRL 
RKGRMMDVK KCGIQDTNS KKQSDTHLE 
ET
      UniProt Q9NZQ7-1

      Programmed cell death 1 ligand 1 isoform 3

      Sequence 
      FTVTVPKDL YVVEYGSNM TIECKFPVE 
KQLDLAALI VYWEMEDKN IIQFVHGEE 
DLKVQHSSY RQRARLLKD QLSLGNAAL 
QITDVKLQD AGVYRCMIS YGGADYKRI 
TVKVNAPYN KINQRILVV DPVTSEHEL 
TCQAEGYPK AEVIWTSSD HQVLSGD
      UniProt Q9NZQ7

      Links to other resources

      UniProt Q9NZQ7
      Ensembl ENST00000381577
      KEGG hsa:29126

      • Anatomical structure: heart

      • Anatomical structure: placenta

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: lung

      • Anatomical structure: spleen

      • Anatomical structure: kidney

      • Anatomical structure: monocyte

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

      • Anatomical structure: keratinocyte

      • Anatomical structure: B-lymphocyte

      • Anatomical structure: T-lymphocyte

      Targets

      CellProgrammed cell death protein 1
      B-lymphocyte Present
      Phenotypes
      • Supression of autoreactive B-lymphocytes
      Reference