Status
Please wait ...

Details for messenger / hormone: uteroglobin

EndoNet ID: ENH00671

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • uteroglobin
  • secretoglobin family 1A member 1
  • clara cell phospholipid-binding protein
  • CCPBP
  • clara cells 10 kDa secretory protein
  • CC10
  • urinary protein 1
  • urine protein 1
  • UP1
  • SCGB1A1
  • CCSP
  • UGB
  • UG
  • blastokinin
  • CC16
  • polychlorobiphenyl binding protein

General information

  • UG binds progesterone, polychlorinated biphenyls, and retinols. [1]
  • Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. [2]
  • UG has potent antiinflammatory and immunomodulatory properties. [1]
  • Homodimeric protein in which the 70 amino acids subunits are connected by two disulfide bonds in an antiparallel orientation. [1]
  • UG shows potent anti-inflammatory activity and inhibitory effects on neutrophil migration, thrombin-induced platelet aggregation, in vitro chemoinvasion, as well as "tumor suppressor"-like effects and other properties. [3]
  • UG is a potent inhibitor of PLA2 activity. [1]
  • Unusually small, spheric uterine secretory molecule without any carbohydrates. [4]
  • UG is normally expressed by most cells of epithelial origin but is known to be lost during the progression of prostate, lung, and uterine cancers to invasive malignancy. [5]
  • Progesterone-dependent secretion of uteroglobin is dose-dependent. [4]
  • IFN-gamma treatment of human bronchial cells induces expression of UG, and the production and biological activity of IFN-gamma are inhibited by UG. [1]
  • Inhibits both chemotaxis and phagocytosis of monocytes and neutrophils. [1]
  • Regulated by estrogen and progesterone in the female reproductive tract, by androgens in the male reproductive tract, by glucocorticoids, IFN-gamma, interleukin-4 and hyperoxia in the lungs. [6]
  • Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. [7]
  • UG has anti-proliferative and anti-metastatic effects in cancer cells. [8]
  • Uteroglobin suppresses SCCA gene expression associated with allergic asthma. [9]
  • UG expression is regulated by progestins, glucocorticoids, androgens, prolactin, and most likely other hormones and cytokines. [3]

Classification

Hormone function

  • development and growth
    • growth inhibition
    • immune response
      • inhibition

      Chemical classification

      Composition

      uteroglobin (2 times)

      Sequence 
      EICPSFQRV IETLLMDTP SSYEAAMEL 
FSPDQDMRE AGAQLKKLV DTLPQKPRE 
SIIKLMEKI AQSSLCN
      UniProt P11684

      Links to other resources

      UniProt P11684
      Ensembl ENST00000278282
      KEGG hsa:7356

      • Anatomical structure: uterus

      • Anatomical structure: epididymis

      • Anatomical structure: lung

      • Anatomical structure: cell_of_endometrium_of_uterus

      • Anatomical structure: thymus

      • Anatomical structure: digestive_system

      • Anatomical structure: pancreas

      • Anatomical structure: mammary_gland

      • Anatomical structure: prostate

      • Anatomical structure: epithelial_cell

      • Anatomical structure: pituitary_gland_of_diencephalon

      Targets

      Cell
      No records found.
      Reference