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Details for messenger / hormone: PGF2-alpha

EndoNet ID: ENH00690

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Synonyms

  • PGF2-alpha
  • prostaglandin F2alpha
  • prostaglandin F2-alpha
  • 9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid

General information

  • 15-keto-PGF2 alpha and 15KD-PGF2 alpha are recognized as metabolite by incubation of PGF2 alpha in uterine homogenate. [1]
  • PGF2-alpha plays an important role in the malignant progression of colorectal tumors. [2]
  • 15-keto-PGF2alpha and 15-keto-13,14 dehydro PGF2alpha are major metabolites of prostaglandin F2alpha in human early placenta. [3]
  • PGF2-alpha has stimulatory effects on hair growth. [4]
  • Cadmium causes a strong induction of testicular PGF2-alpha production. [5]
  • The premature release of PGF2-alpha causes luteal regression in these short cycles. [6]
  • PGF2-alpha triggers cyclin D1 expression via two independent signaling events that complement with TGF(beta1)-triggered events to induce DNA synthesis. [7]
  • 13, 14-dihydro-15-keto-PGF2 alpha and 13, 14-dihydro-PGF2 alpha are recognized as metabolite by incubation of PGF2 alpha in ovarian homogenate. [1]

Classification

Hormone function

  • development and growth
    • growth inhibition

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • prostanoids
            • prostaglandins

      Composition

      Links to other resources

      KEGG C00639
      LIPID MAPS LMFA03010002
      LipidBank XPR1501

        Targets

        CellPGF2-alpha receptor
        colon Present
        placenta Present
        uterus Present
        Reference