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Details for messenger / hormone: IL-28B

EndoNet ID: ENH00699

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Synonyms

  • cytokine Zcyto22
  • interferon lambda-4
  • interferon lambda-3
  • IFN-lambda3
  • Interferon-lambda3
  • Interleukin-28B
  • IL-28B
  • IL-28C
  • Interferon-lambda4
  • IFN-lambda4
  • cytokine ZCYT022
  • Interleukin-28C

General information

  • The type III interefrons show IFN-like activities, but they action through another receptor complex than the type I IFNs. [1]
  • There are signs for an antiviral function of the Interferon-lambdas, but the real antiviral potential in vivo of it, or the mechanism it works is still not clear. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • interferons

      Composition

      Sequence 
      MTGDCMPVL VLMAAVLTV TGAVPVARL 
RGALPDARG CHIAQFKSL SPQELQAFK 
RAKDALEES LLLKDCKCR SRLFPRTWD 
LRQLQVRER PVALEAELA LTLKVLEAT 
ADTDPALGD VLDQPLHTL HHILSQLRA 
CIQPQPTAG PRTRGRLHH WLHRLQEAP 
KKESPGCLE ASVTFNLFR LLTRDLNCV 
ASGDLCV

      Links to other resources

      UniProt Q8IZI9
      Ensembl ENST00000392072
      KEGG hsa:282617

      • Anatomical structure: blood

      • Anatomical structure: brain

      • Anatomical structure: lung

      • Anatomical structure: ovary

      • Anatomical structure: pancreas

      • Anatomical structure: placenta

      • Anatomical structure: prostate

      • Anatomical structure: testis

      Targets

      Reference