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Details for messenger / hormone: IL-20

EndoNet ID: ENH00702

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  • cytokine Zcyto10
  • Interleukin-20
  • IL-20
  • interleukin 20
  • four alpha helix cytokine Zcyto10

General information

  • IL-20 and its receptors were localized in in rheumatoid arthritis synovial fibroblasts. [1]
  • It is known that IL-20 is involved in the pathogenesis of arthritis. IL-20 induced rheumatoid arthritis synovial fibroblasts to secrete RASF migration endothelial cell proliferation monocyte chemoattractant protein1, IL-6 and IL-8 [1]
  • IL-20 even plays a role in epidermal function and psoriasis. [2]
  • IL-20 exerts its proliferative effects indirectly on keratinocytes via immune cells present in the skin. [3]
  • Due to their structural similarity, IL-19, IL-20, IL-22, IL-24 and IL-26 were combined with IL-10 in the so-called IL-10 family. [4]
  • Iinterleukin 20 belongs to a family named IL-10 family. The members are IL-19, IL-20, IL-22, IL-24 and IL-26 [5]


Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • IL-10 family

        Links to other resources

        UniProt Q9NYY1
        Ensembl ENST00000367098
        KEGG hsa:50604
        • Anatomical structure: fibroblast