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Details for messenger / hormone: fetuin-A

EndoNet ID: ENH00704

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Synonyms

  • fetuin-A
  • alpha-2-HS-glycoprotein
  • alpha-2-Z-globulin
  • ba-alpha-2-glycoprotein
  • AHSG
  • fetuin A
  • FETUA
  • alpha2-HSG
  • alpha2-Heremans Schmid glykoprotein
  • alpha2-HS glycoprotein
  • fetuin alpha

General information

  • Fetuin-A is a multifunctional hepatic secretory protein that inhibits the action of insulin in experimental animals. [1]
  • Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. [2]
  • Fetuin-A is a circulating inhibitor of calcification and is regulated as a negative acute phase protein. [3]

Classification

Hormone function

  • homeostasis
    • ion flow control
    • metabolism
      • nutrient supply

      Chemical classification

      • hormone
        • genome-encoded
          • fetuin family

        Composition

        Alpha-2-HS-glycoprotein chain A. (1 times)

        Sequence 
        APHGPGLIY RQPNCDDPE TEEAALVAI 
DYINQNLPW GYKHTLNQI DEVKVWPQQ 
PSGELFEIE IDTLETTCH VLDPTPVAR 
CSVRQLKEH AVEGDCDFQ LLKLDGKFS 
VVYAKCDSS PDSAEDVRK VCQDCPLLA 
PLNDTRVVH AAKAALAAF NAQNNGSNF 
QLEEISRAQ LVPLPPSTY VEFTVSGTD 
CVAKEATEA AKCNLLAEK QYGFCKATL 
SEKLGGAEV AVTCTVFQT QPVTSQPQP 
EGANEAVPT PVVDPDAPP SPPLGAPGL 
PPAGSPPDS HVL
        UniProt P02765

        Alpha-2-HS-glycoprotein chain B. (1 times)

        Sequence 
        TVVQPSVGA AAGPVVPPC PGRIRHFKV
        UniProt P02765

        Links to other resources

        UniProt P02765
        Ensembl ENST00000411641
        KEGG hsa:197

        • Anatomical structure: hepatocyte

          • Ahsg (fetuin-A) is a 55-59kDa phosphorylated glycoprotein synthesized in the adult predominantly by hepatocytes, from which it enters the circulation. [4]

        Targets

        Cellinsulin receptor
        alpha cell of islet of Langerhans Present
        Influences
        • ↓ glucagon
        arcuate nucleus of hypothalamus Present
        Influences
        • ↓ NPY
        • ↓ AGRP
        • ↑ alpha-MSH
        • insulin
        basophil corticotroph cell of anterior pituitary Present
        Phenotypes
        • tertiary adrenal insufficiency
        Influences
        • ↑ ACTH
        • ↑ lipotropin beta
        beta cell of islet of Langerhans Present
        Phenotypes
        • Diabetes mellitus type 2
        • Leprechaunism
        • Diabetes mellitus type 1
        • Maturity onset diabetes of the young
        • Insulimona
        • Hypoglycemia
        Influences
        • ↑ insulin receptor substrate 1
        • insulin
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        Influences
        • ↑ annexin A2
        • NO
        fat cell Present
        Influences
        • ↑ VEGF-165
        • ↑ IL-8
        • ↓ leptin
        heart Present
        skeleton muscle Present
        Reference