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Details for messenger / hormone: galectin-7

EndoNet ID: ENH00741

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Synonyms

  • p53-induced gene 1 protein
  • galectin-7
  • galectin 7
  • LGALS7
  • lectin galactoside-binding soluble 7
  • PIG1
  • TP53I1
  • GAL7
  • Gal-7
  • HKL-14
  • PI7
  • p53-induced protein 1
  • IEF17

General information

  • Galectin-7 modulates the aggressive behavior of lymphoma cells by controlling the expression of metastatic genes, such as MMP-9. [1]
  • May be involved in cancer cell migration.
  • Existing as monomer.
  • Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. [2]
  • Retinoic acid reduces the amount of galectin-7, but does not eliminate it. [3]
  • Galectin-7 is strikingly down-regulated in SV40 transformed keratinocytes. [4]
  • Galectin-7 expression causes enhanced caspase-3 activity and poly(ADP-ribose) polymerase cleavage, and the potentation of apoptosis by galectin-7 is completely abrogated by a caspase inhibitor. [3]
  • Galectin-7 is partially externalized to the medium by keratinocytes although it has no typical secretion signal peptide. [4]
  • GAL7 tends to display pro-apoptotic effects. [3]
  • Galectin-7, designated as the product of the p53-induced gene 1 (PIG1), is a regulator of apoptosis through JNK activation and mitochondrial cytochrome c release. [3]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    Composition

    galectin-7

    Sequence 
    SNVPHKSSL PEGIRPGTV LRIRGLVPP 
NASRFHVNL LCGEEQGSD AALHFNPRL 
DTSEVVFNS KEQGSWGRE ERGPGVPFQ 
RGQPFEVLI IASDDGFKA VVGDAQYHH 
FRHRLPLAR VRLVEVGGD VQLDSVRIF
    UniProt P47929

    Links to other resources

    UniProt P47929
    Ensembl ENST00000378626
    KEGG hsa:653499

    • Anatomical structure: artery

    • Anatomical structure: skin

    • Anatomical structure: epithelial_cell

    • Anatomical structure: keratinocyte

    Targets

    Cell
    No records found.
    Reference