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Details for messenger / hormone: galectin-3-binding protein

EndoNet ID: ENH00742

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Synonyms

  • basement membrane autoantigen p105
  • galectin-3-binding protein
  • galectin 3 binding protein
  • lectin galactoside-binding soluble 3-binding protein
  • mac-2-binding protein
  • mac-2 BP
  • MAC2BP
  • tumor-associated antigen 90K
  • LGALS3BP
  • M2BP
  • MAC-2-BP
  • 90K
  • human lung tumor L3 antigen

General information

  • The serum protein designated 90K/Mac-2BP has been found at elevated concentrations in the sera of patients with various types of cancer and viral infections. [1]
  • Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. [2]
  • M2BP forms linear and ring-shaped oligomers, with each ring segment being composed of two monomers. [3]
  • Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. [4]
  • 90-kD glycoprotein (gp90/Mac-2BP) belongs to the scavenger receptor family, present in normal serum and at increased levels in inflammatory disease and cancer patients, on some T cell function parameters. [5]
  • Mac-2 binding protein is upregulated by hTERT in gastric cancer. [6]
  • Implicated in tumor metastasis.
  • Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. [7]

Classification

Hormone function

  • development and growth
    • growth inhibition
    • immune response
      • activation

      Chemical classification

      Composition

      Galectin-3-binding protein.

      Sequence 
      VNDGDMRLA DGGATNQGR VEIFYRGQW 
GTVCDNLWD LTDASVVCR ALGFENATQ 
ALGRAAFGQ GSGPIMLDE VQCTGTEAS 
LADCKSLGW LKSNCRHER DAGVVCTNE 
TRSTHTLDL SRELSEALG QIFDSQRGC 
DLSISVNVQ GEDALGFCG HTVILTANL 
EAQALWKEP GSNVTMSVD AECVPMVRD 
LLRYFYSRR IDITLSSVK CFHKLASAY 
GARQLQGYC ASLFAILLP QDPSFQMPL 
DLYAYAVAT GDALLEKLC LQFLAWNFE 
ALTQAEAWP SVPTDLLQL LLPRSDLAV 
PSELALLKA VDTWSWGER ASHEEVEGL 
VEKIRFPMM LPEELFELQ FNLSLYWSH 
EALFQKKTL QALEFHTVP FQLLARYKG 
LNLTEDTYK PRIYTSPTW SAFVTDSSW 
SARKSQLVY QSRRGPLVK YSSDYFQAP 
SDYRYYPYQ SFQTPQHPS FLFQDKRVS 
WSLVYLPTI QSCWNYGFS CSSDELPVL 
GLTKSGGSD RTIAYENKA LMLCEGLFV 
ADVTDFEGW KAAIPSALD TNSSKSTSS 
FPCPAGHFN GFRTVIRPF YLTNSSGVD
      UniProt Q08380

      Links to other resources

      UniProt Q08380
      Ensembl ENST00000262776
      KEGG hsa:3959

      • Anatomical structure: blood

      Targets

      Cell
      No records found.
      Reference