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Details for messenger / hormone: VEGFE

EndoNet ID: ENH00760

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Synonyms

  • VEGFE
  • VEGF-E
  • vascular endothelial growth factor E
  • Orf-VEGF

General information

  • VEGFR2-specific ligand, proangiogenic. [1]
  • VEGF-E activates endothelial nitric oxide synthase to induce angiogenesis via cGMP and PKG-independent pathways. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Links to other resources

      Targets

      CellVascular endothelial growth factor receptor 2
      bone marrow Present
      Phenotypes
      • angiogenesis
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Influences
      • ↓ VEGF-165
      microvascularendothelial cell Present
      Influences
      • ↑ von Willebrand factor
      Müllers radial cell of retina Present
      Phenotypes
      • regulation of neural retina development
      sinusoidal endothelial cell Present
      Phenotypes
      • regulation of endothelial cell differentiation
      Reference